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Power-law scaling in intratumoral microbiota of colorectal cancer

2024Journal article Open access
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dc.contributor.authorDovrolis, Nikolas
dc.contributor.authorGazouli, Maria
dc.contributor.authorRigal, François
dc.contributor.authorWhittaker, Robert
dc.contributor.authorMatthews, Thomas J.
dc.contributor.authorGeorgiou, Konstantinos
dc.contributor.authorTheodoropoulos, George
dc.contributor.authorTriantis, Kostas
dc.date.accessioned2024-09-23T10:38:32Z
dc.date.available2024-09-23T10:38:32Z
dc.date.issued2024
dc.description.abstractIt has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDovrolis, N., Gazouli, M., Rigal, F., Whittaker, R. J., Matthews, T. J., Georgiou, K., Theodoropoulos, G., & Triantis, K. A. (2024). Power-law scaling in intratumoral microbiota of colorectal cancer. Gut Pathogens, 16(34), 1-4. DOI:10.1186/s13099-024-00631-x (IF2023 4,3; Q2 Microbiology)pt_PT
dc.identifier.doi10.1186/s13099-024-00631-xpt_PT
dc.identifier.eissn1757-4749
dc.identifier.urihttp://hdl.handle.net/10400.3/7146
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://gutpathogens.biomedcentral.com/articles/10.1186/s13099-024-00631-xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIntratumoral Microbiomept_PT
dc.subjectCancerpt_PT
dc.subjectIsland Species–Area Relationshippt_PT
dc.titlePower-law scaling in intratumoral microbiota of colorectal cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleGut Pathogenspt_PT
oaire.citation.volume16pt_PT
person.familyNameDovrolis
person.familyNameGazouli
person.familyNameRigal
person.familyNameWhittaker
person.familyNameMatthews
person.familyNameGeorgiou
person.familyNameTheodoropoulos
person.familyNameTriantis
person.givenNameNikolas
person.givenNameMaria
person.givenNameFrançois
person.givenNameRobert
person.givenNameThomas
person.givenNameKonstantinos
person.givenNameGeorge
person.givenNameKostas
person.identifier1018558
person.identifier125893
person.identifier.ciencia-idE315-82D2-C35D
person.identifier.ciencia-idE417-973D-F06E
person.identifier.orcid0000-0003-3832-9939
person.identifier.orcid0000-0002-3295-6811
person.identifier.orcid0000-0001-6882-1591
person.identifier.orcid0000-0001-7775-3383
person.identifier.orcid0000-0002-7624-244X
person.identifier.orcid0000-0003-3615-2500
person.identifier.orcid0000-0003-4900-9711
person.identifier.orcid0000-0003-2737-8890
person.identifier.ridI-2572-2018
person.identifier.ridH-1548-2015
person.identifier.scopus-author-id35572899600
person.identifier.scopus-author-id55924714000
person.identifier.scopus-author-id7006063017
person.identifier.scopus-author-id56005200900
person.identifier.scopus-author-id57194035936
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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