Power-law scaling in intratumoral microbiota of colorectal cancer

Dovrolis, Nikolas; Gazouli, Maria; Rigal, François; Whittaker, Robert; Matthews, Thomas J.; Georgiou, Konstantinos; Theodoropoulos, George; Triantis, Kostas

http://hdl.handle.net/10400.3/7146

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Authors

Georgiou, Konstantinos

Theodoropoulos, George

Triantis, Kostas

Abstract(s)

It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

Keywords

Intratumoral Microbiome Cancer Island Species–Area Relationship

URI

http://hdl.handle.net/10400.3/7146

Citation

Dovrolis, N., Gazouli, M., Rigal, F., Whittaker, R. J., Matthews, T. J., Georgiou, K., Theodoropoulos, G., & Triantis, K. A. (2024). Power-law scaling in intratumoral microbiota of colorectal cancer. Gut Pathogens, 16(34), 1-4. DOI:10.1186/s13099-024-00631-x (IF2023 4,3; Q2 Microbiology)