Power-law scaling in intratumoral microbiota of colorectal cancer

Dovrolis, Nikolas; Gazouli, Maria; Rigal, François; Whittaker, Robert; Matthews, Thomas J.; Georgiou, Konstantinos; Theodoropoulos, George; Triantis, Kostas

http://hdl.handle.net/10400.3/7146

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Autores

Georgiou, Konstantinos

Theodoropoulos, George

Triantis, Kostas

Resumo(s)

It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

Palavras-chave

Intratumoral Microbiome Cancer Island Species–Area Relationship

URI

http://hdl.handle.net/10400.3/7146

Citação

Dovrolis, N., Gazouli, M., Rigal, F., Whittaker, R. J., Matthews, T. J., Georgiou, K., Theodoropoulos, G., & Triantis, K. A. (2024). Power-law scaling in intratumoral microbiota of colorectal cancer. Gut Pathogens, 16(34), 1-4. DOI:10.1186/s13099-024-00631-x (IF2023 4,3; Q2 Microbiology)

Editora

Springer Nature

DOI

10.1186/s13099-024-00631-x

Coleções

GBA - Artigos em Revistas Internacionais / Articles in International Journals

Licença CC

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