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The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings

2021-10Journal article Open access
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dc.contributor.authorNavarro-Sempere, Alicia
dc.contributor.authorMartínez-Peinado, Pascual
dc.contributor.authorRodrigues, Armindo
dc.contributor.authorGarcia, Patrícia
dc.contributor.authorCamarinho, Ricardo
dc.contributor.authorGarcía, Magdalena
dc.contributor.authorSegovia, Yolanda
dc.date.accessioned2022-02-14T11:36:14Z
dc.date.available2022-02-14T11:36:14Z
dc.date.issued2021-10
dc.description.abstractNeuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants.en
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNavarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A.S., Garcia, P.V., Camarinho, R., García, M. & Segovia, Y. (2021). The health hazards of volcanoes: first evidence of neuroinflammation in the hippocampus of mice exposed to active volcanic surroundings. “Mediators of Inflammation”, 2021, 5891095. DOI: 10.1155/2021/5891095en
dc.identifier.doi10.1155/2021/5891095pt_PT
dc.identifier.eissn1466-1861
dc.identifier.issn0962-9351
dc.identifier.pmcPMC8523235
dc.identifier.pmid34671225
dc.identifier.urihttp://hdl.handle.net/10400.3/6194
dc.identifier.urihttp://hdl.handle.net/10045/118702
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/mi/2021/5891095/pt_PT
dc.rights© 2021 A. Navarro-Sempere et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCell Biologyen
dc.subjectImmunologyen
dc.subjectHealth Hazardsen
dc.subjectNeuroinflammationpt_PT
dc.subjectVolcanoesen
dc.titleThe Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundingsen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Statesen
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMediators of Inflammationen
oaire.citation.volume2021pt_PT
person.familyNamedos Santos Rodrigues
person.familyNameGarcia
person.familyNameCamarinho
person.givenNameArmindo
person.givenNamePatrícia
person.givenNameRicardo
person.identifier.ciencia-id141A-9835-FBE0
person.identifier.ciencia-id941F-888A-412F
person.identifier.orcid0000-0002-9851-5429
person.identifier.orcid0000-0003-4490-9905
person.identifier.orcid0000-0003-1386-7204
person.identifier.ridM-7754-2013
person.identifier.scopus-author-id7201694062
person.identifier.scopus-author-id55775310500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication375991d8-6f81-4403-902c-000634a4cfdd
relation.isAuthorOfPublication94864ead-4016-4db1-b56e-136d294db238
relation.isAuthorOfPublicationd3673693-ee44-4231-8744-c0b494c0d5d0
relation.isAuthorOfPublication.latestForDiscovery94864ead-4016-4db1-b56e-136d294db238

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