Repository logo
 
Publication

Applications of sesquiterpene lactones : a review of some potential success cases

2020-04Journal article Open access
Simple item page
dc.contributor.authorMoujir, Laila M.
dc.contributor.authorCallies, Oliver
dc.contributor.authorSousa, Pedro M. C.
dc.contributor.authorSharopov, Farukh
dc.contributor.authorSeca, Ana M. L.
dc.date.accessioned2021-03-15T13:01:25Z
dc.date.available2021-03-15T13:01:25Z
dc.date.issued2020-04
dc.description.abstractSesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community.en
dc.description.sponsorshipPortuguese Foundation for Science and Technology; European Commission; QREN; European Commission; COMPETE; cE3c centre (UIDB/00329/2020); LAQV-REQUIMTE (UIDB/50006/2020); QOPNA UID/QUI/00062/2019), Spanish Ministry Science and Research (MINECO RTI2018-094356-B-C21)en
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoujir, L., Callies, O., Sousa, P.M.C., Sharopov, F. & Seca, A.M.L. (2020). Applications of sesquiterpene lactones: a review of some potential success cases. "Applied Sciences", 10(9), 1-32.en
dc.identifier.doi10.3390/app10093001pt_PT
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.3/5791
dc.identifier.wos000535541900014
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/10/9/3001pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAsteraceaept_PT
dc.subjectSesquiterpene Lactonesen
dc.subjectAlantolactoneen
dc.subjectArglabinen
dc.subjectParthenolideen
dc.subjectThapsigarginen
dc.subjectin vivo Studyen
dc.subjectAnticanceren
dc.subjectAnti-inflammatoryen
dc.titleApplications of sesquiterpene lactones : a review of some potential success casesen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlanden
oaire.citation.endPage31pt_PT
oaire.citation.issue(9)pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Sciencesen
oaire.citation.volume10pt_PT
person.familyNameSeca
person.givenNameAna
person.identifier.ciencia-id4518-FF32-251F
person.identifier.orcid0000-0002-7709-2375
person.identifier.ridE-5475-2013
person.identifier.scopus-author-id6603279232
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1c6b511a-fd49-4292-a8a2-b738f558eef1
relation.isAuthorOfPublication.latestForDiscovery1c6b511a-fd49-4292-a8a2-b738f558eef1

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
P1608_Seca_2020_AppliedSciences.pdf
Size:
1.95 MB
Format:
Adobe Portable Document Format
Download

Collections

GBA - Artigos em Revistas Internacionais / Articles in International Journals
DCFQE - Artigos em Revistas Internacionais / Articles in International Journals