Publication
Comparison of Apolipoprotein E polymorphism and other atherosclerotic risk factors in two Portuguese populations: the Influence of Insularity
| dc.contributor.author | Lopes, Paula Alexandra | |
| dc.contributor.author | Gaspar, Gisela | |
| dc.contributor.author | Napoleão, Patrícia | |
| dc.contributor.author | Santos, Maria Cristina | |
| dc.contributor.author | Pavão, Maria Leonor | |
| dc.contributor.author | Viegas-Crespo, Ana Maria | |
| dc.date.accessioned | 2014-02-11T12:31:38Z | |
| dc.date.available | 2014-02-11T12:31:38Z | |
| dc.date.issued | 2007-09 | |
| dc.description.abstract | O principal objectivo deste estudo é o de pesquisar o efeito da insularidade nos polimorfismos da apolipoproteína (apo) E em indivíduos saudáveis do continente (Lisboa) e de Ponta Delgada (Ilha de S. Miguel, Arquipélago dos Açores). Adicionalmente, estudar a distribuição dos seus genótipos em doentes com aterosclerose da Ilha de S. Miguel. Em Lisboa, a distribuição dos genótipos da apo E foi a seguinte: e3/e3 > e3/e4 > e2/e3 > e4/e4, ao passo que em Ponta Delgada e independentemente da condição fisiológica foi: e3/e3 > e2/e3 > e3/e4. Distintas frequências genotípicas foram observadas entre homens e mulheres no grupo saudável de Ponta Delgada. O índice de massa corporal, hipertensão arterial e perfil lipídico, factores de risco associados ao processo aterosclerótico, revelaram algumas diferenças quando avaliados em função dos grupos alélicos. Neste estudo, os genótipos de risco da apo E, e2/e2 and e2/e4, não foram contabilizados. Curiosamente a proporção dos genótipos nas mulheres foi heterogénea nos 3 grupos estudados. | por |
| dc.description.abstract | ABSTRACT: The main objective of this study was to investigate the apolipoprotein (apo) E genotypes in Portuguese populations from mainland (Lisbon city) and from San Miguel Island, Azores’ Archipelago (Ponta Delgada city) and to look for differences between these particular sites in apparently healthy subjects. Also, subjects with clinical diagnosis of atherosclerotic disease were investigated in San Miguel Island. In Lisbon, the genotypes distribution was: e3/e3 > e3/e4 > e2/e3 > e4/e4 while that, for Ponta Delgada and regardless the health condition, was: e3/e3 > e2/e3 > e3/e4. Within Ponta Delgada control group, females and males had distinct genotype frequencies. The most common atherosclerotic risk factors as body mass index, blood hypertension and serum lipid parameters, presented some differences among the allelic subgroups of apo E. The major conclusions were: 1) an apparent influence of insularity in apo E polymorphism was observed; 2) both the high risk genotypes e2/e2 and e2/e4 were not found, even in patients; 3) curiously, the genotypes proportion in females was not homogenous among the three groups. | en |
| dc.description.sponsorship | Fundação para a Ciência e a Tecnologia; Centro de Biologia Ambiental (FCUL); Instituto de Investigação Científica Bento da Rocha Cabral. | por |
| dc.identifier.citation | LOPES, P. A., GASPAR, G., NAPOLEÃO, P., SANTOS, M. C., PAVÃO, M. L. e VIEGAS-CRESPO, A. M. (2007). "Comparison of Apolipoprotein E polymorphism and other atherosclerotic risk factors in two Portuguese populations: the Influence of Insularity", Brazilian Archives of Biology and Technology, 50(5): 803-813. ISSN 1516-8913. | en |
| dc.identifier.issn | 1516-8913 (Print) | |
| dc.identifier.issn | 1678-4324 (Online) | |
| dc.identifier.uri | http://hdl.handle.net/10400.3/2743 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Technology Institute of Paraná - Tecpar | por |
| dc.relation | Markers of the prooxidant/antioxidant balance and characterization of the allelic profile of apo E in inhabitants of Lisbon and Ponta Delgada | |
| dc.relation.publisherversion | http://dx.doi.org/10.1590/S1516-89132007000500008 | por |
| dc.subject | Apolipoprotein E Polymorphism | en |
| dc.subject | Cardiovascular Risk Factors | en |
| dc.subject | Atherosclerosis | en |
| dc.subject | Insularity | en |
| dc.title | Comparison of Apolipoprotein E polymorphism and other atherosclerotic risk factors in two Portuguese populations: the Influence of Insularity | en |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Markers of the prooxidant/antioxidant balance and characterization of the allelic profile of apo E in inhabitants of Lisbon and Ponta Delgada | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCTI%2FESP%2F41008%2F2001/PT | |
| oaire.citation.endPage | 813 | por |
| oaire.citation.issue | (5) | por |
| oaire.citation.startPage | 803 | por |
| oaire.citation.title | Brazilian Archives of Biology and Technology | en |
| oaire.citation.volume | 50 | por |
| oaire.fundingStream | POCI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isProjectOfPublication | b5aee06b-d4f3-4fc9-a05e-108e590dd046 | |
| relation.isProjectOfPublication.latestForDiscovery | b5aee06b-d4f3-4fc9-a05e-108e590dd046 |