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Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

2020-08Journal article Open access
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dc.contributor.authorZárate, Rafael
dc.contributor.authorPortillo, Eduardo
dc.contributor.authorTeixidó, Sílvia
dc.contributor.authorCarvalho, Miguel A. A. Pinheiro de
dc.contributor.authorNunes, Nuno
dc.contributor.authorFerraz, Sónia
dc.contributor.authorSeca, Ana M. L.
dc.contributor.authorRosa, Gonçalo P.
dc.contributor.authorBarreto, Maria do Carmo
dc.date.accessioned2021-03-12T17:14:39Z
dc.date.available2021-03-12T17:14:39Z
dc.date.issued2020-08
dc.description.abstractSeaweed beach-casts are a seasonal phenomenon that regularly deposits tons of algae biomass on beaches, which are usually disposed of in landfills. The present work aimed to contribute to the valorization of this biomass by studying bioactivities that reveal its potential in the pharmaceutical and/or cosmeceutical industries. Methanol and ethanol extracts and fractions from 15 beach-casts biomass were tested for a range of bioactivities. Eight of the most active samples exhibit IC50 values between 11.38 µg/mL and 19.28 µg/mL and selectivity indexes higher than 3.8, against NCI-H1299 (lung cancer) and T47D (breast cancer). Concerning antiaging potential, all the extracts tested presented UV protection, with SPF values above 30, like the standard sunscreen. Regarding aging-related enzymes, 24 samples were tyrosinase inhibitors exhibiting IC50 values from 9.01 µg/mL to 200.09 µg/mL. Eight extracts inhibited collagenase (IC50 < 248.76 µg/mL), two of them more actively than positive control EDTA (IC50 = 59.26 µg/mL). In addition to UV protection, the cumulative effect of antityrosinase and anticollagenase activities shown by the samples suggest that they may play a significant role in preventing skin photoaging. The results obtained demonstrate the high potential of beach-cast seaweed biomass as sources of cosmetic bioproducts with antiaging effects, and of selective cytotoxic metabolites.en
dc.description.sponsorshipThis research was funded by project MACBIOBLUE (MAC/1.1b/086), program Interreg MAC 2014-2020, namely supporting G.P.R.'s grant, co-financed by DRCT (Azores Regional Government), as well as by FCT-Fundacao para a Ciencia e Tecnologia, the European Union, QREN, FEDER, and COMPETE, through funding the cE3c center (UIDB/00329/2020) and the LAQV-REQUIMTE (UIDB/50006/2020). S.T. acknowledges funding from Cabildo Insular de Gran Canaria, Spain (project 01010311480000120). This work was supported also by the program PO Madeira 14-20, ref. M1420-01-0145-FEDER-000011, through ISOPlexis Center, and ARDITI.en
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZárate, R., Portillo, E., Teixidó, S., Carvalho, M.A.A.P., Nunes, N., Ferraz, S., Seca, A.M.L., Rosa, G.P. & Barreto, M.C. (2020). Pharmacological and cosmeceutical potential of seaweed beach-casts of Macaronesia. "Applied Sciences", 10(17), 5831. DOI:10.3390/app10175831en
dc.identifier.doi10.3390/app10175831pt_PT
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.3/5785
dc.identifier.wos000569801600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/10/17/5831pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectUV Protectionen
dc.subjectAntityrosinaseen
dc.subjectAntiagingen
dc.subjectAnticanceren
dc.subjectBiomass Valorizationen
dc.subjectBeach-cast Seaweedsen
dc.titlePharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesiaen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlanden
oaire.citation.endPage24pt_PT
oaire.citation.issue(17)pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Sciencesen
oaire.citation.volume10pt_PT
person.familyNameSeca
person.familyNameRosa
person.familyNameBarreto
person.givenNameAna
person.givenNameGonçalo
person.givenNameMaria do Carmo
person.identifier.ciencia-id4518-FF32-251F
person.identifier.ciencia-idC512-A6FD-4A68
person.identifier.orcid0000-0002-7709-2375
person.identifier.orcid0000-0002-0706-8505
person.identifier.orcid0000-0001-5797-8913
person.identifier.ridE-5475-2013
person.identifier.ridN-8704-2015
person.identifier.scopus-author-id6603279232
person.identifier.scopus-author-id7004455600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationf61a2d4d-efd3-487c-acfb-7bb7aceb55b0
relation.isAuthorOfPublication.latestForDiscovery848abdd5-db5c-4194-9b8a-4aada01290ce

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