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Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents

2023Journal article Open access
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dc.contributor.authorMota, Sandra
dc.contributor.authorRosa, Gonçalo P.
dc.contributor.authorBarreto, Maria Carmo
dc.contributor.authorGarrido, Jorge
dc.contributor.authorSousa, Emília
dc.contributor.authorCruz, Maria Teresa
dc.contributor.authorAlmeida, Isabel F.
dc.contributor.authorQuintas, Clara
dc.date.accessioned2024-07-04T11:08:13Z
dc.date.available2024-07-04T11:08:13Z
dc.date.issued2023
dc.description.abstractDepigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase inhibition was compared, and cell viability was assessed in B-16V melanocytes to evaluate safety. Results showed 4-butylresorcinol, ascorbyl glucoside, and α-arbutin are non-photoreactive, while for ascorbic acid and bakuchiol it was not possible to reach conclusive results due to the lack of specificity of the ROS assay. 4-Butylresorcinol, acting as a competitive inhibitor, displayed potent tyrosinase inhibition, followed by ascorbic acid and bakuchiol. Both 4-butylresorcinol and bakuchiol reduced cell viability in a concentration-dependent manner. The insights obtained in this work support the development of depigmenting products by providing useful scientific guidance on the photostability, tyrosinase inhibitory efficacy, and skin safety of depigmenting agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMota, S., Rosa, G. P., Barreto, M. C., Garrido, J., Sousa, E., Cruz, M. T., Almeida, I. F., & Quintas, C. (2024). Comparative studies on the photoreactivity, efficacy, and safety of depigmenting agents. "Pharmaceuticals", 17(1), 55. DOI:10.3390/ph17010055pt_PT
dc.identifier.doi10.3390/ph17010055pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10400.3/7079
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1424-8247/17/1/55pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDepigmenting Agentspt_PT
dc.subjectCosmeticpt_PT
dc.subjectSkin Pigmentationpt_PT
dc.subjectPhotoreactivitypt_PT
dc.subjectTyrosinase Inhibitionpt_PT
dc.subjectMelanocytespt_PT
dc.subjectCytotoxicitypt_PT
dc.titleComparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue1pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume17pt_PT
person.familyNameda Silva Mota
person.familyNameRosa
person.familyNameBarreto
person.familyNameGarrido
person.familyNameSousa
person.familyNameCruz
person.familyNameFerreira de Oliveira Quintas
person.givenNameSandra Filipa
person.givenNameGonçalo
person.givenNameMaria Carmo
person.givenNameJorge
person.givenNameEmília
person.givenNameMaria Teresa
person.givenNameMaria Clara
person.identifierD-4771-2013
person.identifier.ciencia-id021F-D6F8-57BA
person.identifier.ciencia-idC312-BBB1-107A
person.identifier.ciencia-id1118-47DC-43CB
person.identifier.ciencia-id8811-FE8F-3A39
person.identifier.orcid0000-0001-5348-8431
person.identifier.orcid0000-0002-0706-8505
person.identifier.orcid0000-0001-8377-616X
person.identifier.orcid0000-0001-8981-231X
person.identifier.orcid0000-0003-4331-802X
person.identifier.orcid0000-0002-4839-9052
person.identifier.orcid0000-0002-2087-1773
person.identifier.scopus-author-id37076751100
person.identifier.scopus-author-id7202779733
person.identifier.scopus-author-id16405176000
person.identifier.scopus-author-id8684906900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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