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Ionic Liquids and Deep Eutectic Solvents for Polyphenol Extraction: Opportunities and Limitations

2026-04-15Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Médicas::Biotecnologia Médica
dc.contributor.authorRosa, Gonçalo
dc.contributor.authorBarreto, Maria do Carmo
dc.contributor.authorSeca, Ana
dc.contributor.authorPinto, Diana
dc.contributor.editorVlase, Ana-Maria
dc.date.accessioned2026-05-11T13:42:41Z
dc.date.available2026-05-11T13:42:41Z
dc.date.issued2026-04-15
dc.description.abstractPolyphenols are structurally diverse plant secondary metabolites with broad biological activities and growing applications across the food, health, and materials sectors. Conventional extraction based on organic solvents (e.g., methanol, ethanol) is often energy-intensive, inefficient, and environmentally burdensome. Ionic liquids (ILs) and deep eutectic solvents (DESs) have therefore emerged as greener alternatives for polyphenol extraction. This review evaluates recent advances in solvent design, extraction performance, and process sustainability. Imidazolium-based ILs frequently achieve high yields and selectivity, particularly when coupled with ultrasound or microwave-assisted extraction, but high cost, synthetic complexity, viscosity-related constraints, and potential toxicity hinder scaleup. By contrast, DESs—especially those derived from choline chloride or lactic acid—are easier to prepare, less costly, and more compatible with industrial implementation, with efficiency enhanced by tailoring hydrogen bond networks, water content, and process intensification. Critical downstream challenges persist for both solvent classes, notably in extract purification and solvent recovery due to low volatility; approaches such as resin adsorption, antisolvent precipitation, and direct formulation have been explored. Overall, ILs and DESs represent compelling alternatives to conventional solvents, and future progress will depend on integrated extraction–recovery strategies, systematic solvent selection, and validation under scalable, sustainable processing conditions.eng
dc.identifier.citationRosa, G. P., Barreto, M. C., Seca, A. M. L. & Pinto, D. C. G. A. (2026). Ionic Liquids and Deep Eutectic Solvents for Polyphenol Extraction: Opportunities and Limitations. International Journal of Molecular Sciences, 27(8), 3538.
dc.identifier.doi10.3390/ijms27083538
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.3/8949
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationFCT - UID/00329/2025—Centre for Ecology, Evolution and Environmental Changes (CE3C) (https://doi.org/10.54499/UID/00329/2025)
dc.relationUID/50006/2025-Laboratório Associado para a Química Verde—Tecnologias e Processos Limpos
dc.relationRegional Directorate for Science, Innovation and Development [Regional Government of the Azores] - PROSCIENTIA Incentive System (M1.1.A/FUNC.UI&D/021/2025 [UI&D/GBA/2025]
dc.relationInterreg project Natur-Ext (1/MAC/2/2.6/0075) - FEDER (85%) and the Azores’ DRCID (15%)
dc.relationPROSCIENTIA Incentive System (M2.2.A/COFUND MAC/003/2024/UAc and FGF)
dc.relation.hasversionhttps://www.mdpi.com/1422-0067/27/8/3538
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectpolyphenols
dc.subjectionic liquids
dc.subjectdeep eutectic solvents
dc.subjectsustainability
dc.subjectflavonoids
dc.subjecttannins
dc.titleIonic Liquids and Deep Eutectic Solvents for Polyphenol Extraction: Opportunities and Limitationseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.startPage3538
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume27
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRosa
person.familyNameBarreto
person.familyNameSeca
person.givenNameGonçalo
person.givenNameMaria do Carmo
person.givenNameAna
person.identifier.ciencia-id4518-FF32-251F
person.identifier.orcid0000-0002-0706-8505
person.identifier.orcid0000-0003-1434-0148
person.identifier.orcid0000-0002-7709-2375
person.identifier.ridE-5475-2013
person.identifier.scopus-author-id6603279232
relation.isAuthorOfPublication848abdd5-db5c-4194-9b8a-4aada01290ce
relation.isAuthorOfPublicationc5dab5bf-1dfa-4d2b-8434-b0539fb5a4ae
relation.isAuthorOfPublication1c6b511a-fd49-4292-a8a2-b738f558eef1
relation.isAuthorOfPublication.latestForDiscovery848abdd5-db5c-4194-9b8a-4aada01290ce

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