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Common polygenic variation contributes to risk of schizophrenia and bipolardisorder

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dc.contributor.authorPurcell, S. M.
dc.contributor.authorWray, N. R.
dc.contributor.authorStone, J. L.
dc.contributor.authorVisscher, P. M.
dc.contributor.authorO'Donovan, M. C.
dc.contributor.authorSullivan, P. F.
dc.contributor.authorSklar, P.
dc.contributor.authorLeader, S. M.
dc.contributor.authorRuderfer, D. M.
dc.contributor.authorMcQuillin, A.
dc.contributor.authorMorris, D. W.
dc.contributor.authorO'Dushlaine, C. T.
dc.contributor.authorCorvin, A.
dc.contributor.authorHolmans, P. A.
dc.contributor.authorMacgregor, S.
dc.contributor.authorGurling, H.
dc.contributor.authorBlackwood, D. H.
dc.contributor.authorCraddock, N. J.
dc.contributor.authorGill, M.
dc.contributor.authorHultman, C. M.
dc.contributor.authorKirov, G. K.
dc.contributor.authorLichtenstein, P.
dc.contributor.authorMuir, W. J.
dc.contributor.authorOwen, M. J.
dc.contributor.authorPato, Carlos N.
dc.contributor.authorScolnick, E. M.
dc.contributor.authorSt Clair, D.
dc.contributor.authorWilliams, N. M.
dc.contributor.authorGeorgieva, L.
dc.contributor.authorNikolov, I.
dc.contributor.authorNorton, N.
dc.contributor.authorWilliams, H.
dc.contributor.authorToncheva, D.
dc.contributor.authorMilanova, V.
dc.contributor.authorHelander, E. F.
dc.contributor.authorKenny, E.
dc.contributor.authorQuinn, E. M.
dc.contributor.authorChoudhury, K.
dc.contributor.authorDatta, S.
dc.contributor.authorPimm, J.
dc.contributor.authorThirumalai, S.
dc.contributor.authorPuri, V.
dc.contributor.authorKrasucki, R.
dc.contributor.authorLawrence, J.
dc.contributor.authorQuested, D.
dc.contributor.authorBass, N.
dc.contributor.authorCrombie, C.
dc.contributor.authorFraser, G.
dc.contributor.authorLeh, K. S.
dc.contributor.authorWalker, N.
dc.contributor.authorBlack-wood, D. H.
dc.contributor.authorMcGhee, K. A.
dc.contributor.authorPickard, B.
dc.contributor.authorMalloy, P.
dc.contributor.authorMaclean, A. W.
dc.contributor.authorVan Beck, M.
dc.contributor.authorPato, Michele T.
dc.contributor.authorMedeiros, Helena
dc.contributor.authorMiddleton, Frank A.
dc.contributor.authorCarvalho, Célia
dc.contributor.authorMorley, C.
dc.contributor.authorFanous, Ayman H.
dc.contributor.authorConti, D.
dc.contributor.authorKnowles, James A.
dc.contributor.authorFerreira, Carlos Paz
dc.contributor.authorMacedo, António
dc.contributor.authorKirby, A. N.
dc.contributor.authorFerreira, M. A.
dc.contributor.authorDaly, M. J.
dc.contributor.authorCham-bert, K.
dc.contributor.authorKuruvilla, F.
dc.contributor.authorGabriel, S. B.
dc.contributor.authorArdlie, K.
dc.contributor.authorMoran, J. L.
dc.date.accessioned2017-02-24T18:21:46Z
dc.date.available2017-02-24T18:21:46Z
dc.date.issued2009
dc.description.abstractSchizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.en
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPurcell, S.M., Wray, N.R., Stone, J.L., Visscher, P.M., O'Donovan, M.C., Sullivan, P.F., Sklar, P., Purcell., Leader, S.M., Ruderfer, D.M., McQuillin, A., Morris, D.W., O'Dushlaine, C.T., Corvin, A., Holmans, P.A., Macgregor, S., Gurling, H., Blackwood, D.H., Craddock, N.J., Gill, M., Hultman, C.M., Kirov, G.K., Lichtenstein, P., Muir, W.J., Owen, M.J., Pato, C.N., Scolnick, E.M., St Clair, D, Williams, N.M., Georgieva, L., Nikolov, I., Norton, N., Williams, H., Toncheva, D., Milanova, V., Thelander, E.F., Kenny ,E., Quinn, E.M., Choudhury, K., Datta, S., Pimm, J., Thirumalai, S., Puri, V., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Crombie, C., Fraser, G., Leh, K.S., Walker, N., Black-Wood, D.H., McGhee, K.A., Pickard, B., Malloy, P., Maclean, A.W., Van Beck, M., Pato, M.T., Medeiros, H., Middleton, F., Carvalho, C., Morley, C., Fanous, A., Conti, D., Knowles, J.A., Paz, F.C., Macedo, A., Helena, A.M., Kirby, A.N., Ferreira, M.A., Daly, M.J., Cham-bert, K., Kuruvilla, F., Gabriel, S.B., Ardlie, K. & Moran, J.L. (2009). Common polygenic variation contributes to risk of schizophrenia and bipolardisorder. "Nature", 460(7256), 748-752.en
dc.identifier.doi10.1038/nature08185pt_PT
dc.identifier.issn1476-4687 (Online)
dc.identifier.urihttp://hdl.handle.net/10400.3/3997
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Groupen
dc.relation.publisherversionhttp://www.nature.com/nature/journal/v460/n7256/full/nature08185.htmlpt_PT
dc.subjectSchizophreniaen
dc.subjectPsychiatric Disorderen
dc.subjectGenome Scansen
dc.titleCommon polygenic variation contributes to risk of schizophrenia and bipolardisorderen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage752pt_PT
oaire.citation.startPage748pt_PT
oaire.citation.titleNatureen
oaire.citation.volume460pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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