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Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions

2021-07Journal article Restricted access
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dc.contributor.authorCamarinho, Ricardo
dc.contributor.authorGarcia, Patrícia
dc.contributor.authorChoi, Hyunok
dc.contributor.authorRodrigues, Armindo
dc.date.accessioned2022-02-14T10:55:28Z
dc.date.available2022-02-14T10:55:28Z
dc.date.issued2021-07
dc.description.abstractRecent studies have shown that exposure to hydrothermal emissions has a negative impact on the respiratory system. Still, volcanogenic air pollution studies are still outnumbered when compared to anthropogenic studies which can result in an unknown risk to the human populations living near volcanically active areas. This study was carried out in São Miguel Island, with noneruptive volcanically active environments, such as the Furnas volcano caldera. Its noneruptive volcanism presents itself as hydrothermal emissions, mainly by the release of nearly 1000 T d-1 of CO₂ along with H₂S, and the radioactive gas radon; metals [e.g., mercury (Hg), cadmium (Cd), copper (Cu), and zinc (Zn)] and particulate matter are also released in a daily basis. We test the hypothesis whether chronic exposure to hydrothermal emissions causes pulmonary oxidative stress, using Mus musculus as a surrogate species. Mus musculus was live-captured in two villages with hydrothermal emissions and one village without any type of volcanic activity. The level of pulmonary oxidative stress was immunohistochemically assessed by using an OxyIHCTM Oxidative stress detection kit, and the detection of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) was used to evaluate apoptosis in lung tissues. Mice chronically exposed to hydrothermal emissions presented increased levels of oxidative stress and amount of apoptotic cells. We demonstrate, for the first time, the high oxidative stress potential in the lungs of mice chronically exposed to hydrothermal emissions. This study highlights the usefulness of M. musculus as a bioindicator species and enforces the necessity of regularly biomonitor the inhabitants of hydrothermal areas to prevent respiratory pathologies.en
dc.description.sponsorshipRicardo Camarinho is currently supported by a PhD fellowship grant (M3.1.a/F/048/2015) from Fundo Regional da Ciencia (Regional Government of the Azores).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCamarinho, R., Garcia, P.V., Choi, H. & Rodrigues, A.S. (2021). Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions. “Environmental Science & Pollution Research”, 28(27), 35709-35716. DOI: 10.1007/s11356-021-13043-0en
dc.identifier.doi10.1007/s11356-021-13043-0pt_PT
dc.identifier.eissn1614-7499
dc.identifier.issn0944-1344
dc.identifier.pmid33675493
dc.identifier.urihttp://hdl.handle.net/10400.3/6193
dc.identifier.wos000625738500007
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Science and Business Media LLCen
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11356-021-13043-0pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAir Pollutionen
dc.subjectMus musculuspt_PT
dc.subjectNoneruptive Volcanismen
dc.subjectOxidative Stressen
dc.subjectTUNEL Assayen
dc.titlePulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissionsen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceGermanyen
oaire.citation.endPage35716pt_PT
oaire.citation.issue(27)pt_PT
oaire.citation.startPage35709pt_PT
oaire.citation.titleEnvironmental Science and Pollution Researchen
oaire.citation.volume28pt_PT
person.familyNameCamarinho
person.familyNameGarcia
person.familyNamedos Santos Rodrigues
person.givenNameRicardo
person.givenNamePatrícia
person.givenNameArmindo
person.identifier.ciencia-id941F-888A-412F
person.identifier.ciencia-id141A-9835-FBE0
person.identifier.orcid0000-0003-1386-7204
person.identifier.orcid0000-0003-4490-9905
person.identifier.orcid0000-0002-9851-5429
person.identifier.ridM-7754-2013
person.identifier.scopus-author-id55775310500
person.identifier.scopus-author-id7201694062
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd3673693-ee44-4231-8744-c0b494c0d5d0
relation.isAuthorOfPublication94864ead-4016-4db1-b56e-136d294db238
relation.isAuthorOfPublication375991d8-6f81-4403-902c-000634a4cfdd
relation.isAuthorOfPublication.latestForDiscovery94864ead-4016-4db1-b56e-136d294db238

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