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Reactive astrogliosis in the dentate gyrus of mice exposed to active volcanic environments

2021-03Journal article Open access
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dc.contributor.authorNavarro-Sempere, Alicia
dc.contributor.authorGarcía, M.
dc.contributor.authorRodrigues, Armindo
dc.contributor.authorGarcia, Patrícia
dc.contributor.authorCamarinho, Ricardo
dc.contributor.authorSegovia, Yolanda
dc.date.accessioned2021-09-24T11:19:22Z
dc.date.available2022-03-01T01:30:15Z
dc.date.issued2021-03
dc.description.abstractAir pollution has been associated with neuroinflammatory processes and is considered a risk factor for the development of neurodegenerative diseases. Volcanic environments are considered a natural source of air pollution. However, the effects of natural source air pollution on the central nervous system (CNS) have not been reported, despite the fact that up to 10% of the world’s population lives near a historically active volcano. In order to assess the response of the CNS to such exposure, our study was conducted in the island of Sao Miguel (Azores, Portugal) in two different areas: Furnas, which is volcanically active one, and compared to Rabo de Peixe, a reference site without manifestations of active volcanism using Mus musculus as a bioindicator species. To evaluate the state of the astroglial population in the dentate gyrus in both samples, the number of astrocytes was determined using immunofluorescence methods (anti-GFAP and anti-GS). In addition, the astrocytic branches in that hippocampal area were examined. Our results showed an increase in GFAP+ astrocytes and a reduction in GS+ astrocytes in Furnas-exposed mice compared to animals from Rabo de Peixe. In addition, astrocytes in the dentate gyrus of chronically exposed animals exhibited longer branches compared to those residing at the reference site. Thus, reactive astrogliosis and astrocyte dysfunction are found in mice living in an active volcanic environment.en
dc.description.sponsorshipThis research was supported by the University of Alicante VIGROB-186.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNavarro-Sempere, A., García, M., Rodrigues, A.S., Garcia, P.V., Camarinho, R. & Segovia, Y. (2021). Reactive astrogliosis in the dentate gyrus of mice exposed to active volcanic environments. "Journal of Toxicology and Environmental Health, Part A: Current Issues", 84(5), 213-226. DOI:10.1080/15287394.2020.1850381en
dc.identifier.doi10.1080/15287394.2020.1850381pt_PT
dc.identifier.eissn1087-2620
dc.identifier.issn1528-7394
dc.identifier.pmid33283687
dc.identifier.urihttp://hdl.handle.net/10400.3/6072
dc.identifier.wos000596328600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francisen
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/15287394.2020.1850381pt_PT
dc.subjectGlial Fibrillary Acidic Proteinen
dc.subjectAstrocytesen
dc.subjectMus musculuspt_PT
dc.subjectNeurotoxicityen
dc.titleReactive astrogliosis in the dentate gyrus of mice exposed to active volcanic environmentsen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited Kingdompt_PT
oaire.citation.endPage226pt_PT
oaire.citation.issue(5)pt_PT
oaire.citation.startPage213pt_PT
oaire.citation.titleJournal of Toxicology and Environmental Health, Part Aen
oaire.citation.volume84pt_PT
person.familyNamedos Santos Rodrigues
person.familyNameGarcia
person.givenNameArmindo
person.givenNamePatrícia
person.identifier.ciencia-id141A-9835-FBE0
person.identifier.ciencia-id941F-888A-412F
person.identifier.orcid0000-0002-9851-5429
person.identifier.orcid0000-0003-4490-9905
person.identifier.ridM-7754-2013
person.identifier.scopus-author-id7201694062
rcaap.embargofctRequisito do Periódico (Sherpa/Romeo)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication375991d8-6f81-4403-902c-000634a4cfdd
relation.isAuthorOfPublication94864ead-4016-4db1-b56e-136d294db238
relation.isAuthorOfPublication.latestForDiscovery94864ead-4016-4db1-b56e-136d294db238

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