Synthesis of new 1,8-dihydroxy-9h-xanthen-9-ones

Leal, Stephanie B.; Seca, Ana M. L.; Pinto, Diana C. G. A.; Silva, Artur M. S.; Cavaleiro, José A. S.

Publication

Synthesis of new 1,8-dihydroxy-9h-xanthen-9-ones

2012-08Conference object

dc.contributor.author	Leal, Stephanie B.
dc.contributor.author	Seca, Ana M. L.
dc.contributor.author	Pinto, Diana C. G. A.
dc.contributor.author	Silva, Artur M. S.
dc.contributor.author	Cavaleiro, José A. S.
dc.date.accessioned	2014-03-28T13:33:16Z
dc.date.available	2014-03-28T13:33:16Z
dc.date.issued	2012-08
dc.description	XXVth European Colloquium on Heterocyclic Chemistry, Reading, UK, 13 – 17 Agosto de 2012.	en
dc.description.abstract	Xanthones have a rather restricted occurrence among higher plants, being found almost exclusively in Guttiferae and Gentianaceae. Xanthones are sometimes found as polyhydroxylated derivatives, exhibiting valuable biological activities [1], but more often bearing a variety of substituents. Xanthones are well known for their interesting phytochemical properties, which make them attractive to the pharmaceutical industry. Natural and synthetic derivatives have been described as exhibiting several important biological properties, such as anti-tumor [2], anti-inflammatory [3], antioxidant [4] and anticoagulant/antiplatelet activities [5]. Owing to our continuing interest in the synthesis of novel oxygen heterocycles we have recently developed an unique synthetic procedure towards the synthesis of new (E)-3-aryl-4-benzylidene-8-hydroxy-3,4-dihydro-1H-xanthene-1,9(2H)-diones (2) [6]. In the sequence of that work and pursuing our objective to synthesize xanthone derivatives with potential biological activities, we set up a program aiming the transformation of xanthenediones (2) into new 1,8-dihydroxy-9H-xanthen-9-one derivatives (3). The experimental procedure and the structural characterization (1D and 2D NMR) of the new compounds will be presented and discussed.	en
dc.description.sponsorship	Thanks are due to the University of Aveiro, Fundação para a Ciência e a Tecnologia (FCT) and FEDER for funding the Organic Chemistry Research Unit (project PEst-C/QUI/UI0062/2011). We are also grateful to the Portuguese National NMR Network (RNRMN) supported with funds from FCT.	en
dc.identifier.citation	Leal, Stéphanie B.; Seca, Ana M. L.; Pinto, Diana C. G. A.; Silva, Artur M. S.; Cavaleiro, José A. S. (2012). "Synthesis of new 1,8-dihydroxy-9h-xanthen-9-ones". XXVth European Colloquium on Heterocyclic Chemistry, Reading, UK, 13 – 17 Agosto de 2012, PO-36 (Poster Presentations).	en
dc.identifier.uri	http://hdl.handle.net/10400.3/2923
dc.language.iso	eng	por
dc.peerreviewed	yes	por
dc.publisher	XXVth European Colloquium on Heterocyclic Chemistry	en
dc.relation	Strategic Project - UI 62 - 2011-2012
dc.subject	Xanthones	por
dc.subject	Synthesis	en
dc.subject	1,8-dihydroxy-9H-xanthen-9-one	por
dc.subject	Xanthenediones	por
dc.title	Synthesis of new 1,8-dihydroxy-9h-xanthen-9-ones	en
dc.type	conference object
dspace.entity.type	Publication
oaire.awardTitle	Strategic Project - UI 62 - 2011-2012
oaire.awardURI	info:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FQUI%2FUI0062%2F2011/PT
oaire.citation.conferencePlace	Reading, UK	en
oaire.citation.startPage	PO-36	por
oaire.citation.title	XXVth European Colloquium on Heterocyclic Chemistry	en
oaire.fundingStream	6820 - DCRRNI ID
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	por
rcaap.type	conferenceObject	por
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