New xanthenodione: synthesis and antioxidant activity evaluation

Leal, Stephanie B.; Pinto, Diana C. G. A.; Seca, Ana M. L.; Silva, Artur M. S.; Cavaleiro, José A. S.

http://hdl.handle.net/10400.3/2933

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Authors

Leal, Stephanie B.

Pinto, Diana C. G. A.

Seca, Ana M. L.

Silva, Artur M. S.

Cavaleiro, José A. S.

Abstract(s)

Due to the continuing interest of the research group in the synthesis of novel oxygen heterocycles we have recently developed a unique synthetic route towards new xanthenodiones 5 (scheme 1).[6] The application of this methodology in the cyclization of chromone derivatives 4b,c bearing methoxyl groups not only promote the cyclization to xanthenedione derivatives but also promote the demethylation leading to the 4-(benzylidene)-8-hydroxy-3-phenyl-3,4-dihydro-1H-xanthene-1,9(2H)-diones 5b,c . This interesting result prompted us to investigate the antioxidant potential of 4-(benzylidene)-8-hydroxy-3-phenyl-3,4-dihydro-1H-xanthene-1,9(2H)-diones 5a-c .

Description

6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, Lisboa, de 18 a 20 de Julho de 2012 (Poster Communication).

Keywords

Xantenodiones Antioxidant Reducing Power

URI

http://hdl.handle.net/10400.3/2933

Citation

Leal, S. B.; Pinto, Diana C. G. A.; Seca, A. M. L.; Silva, A. M. S.; Cavaleiro, J. A. S. (2012). "New xanthenodione: synthesis and antioxidant activity evaluation". 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, Lisboa, 18 a 20 Julho 2012, P37, Book of Abstracts, pag. 105.