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Origanum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens Essential Oils: Chemotypes and Bioactivity as Antifungal, Antifeeding and Enzyme Inhibitors

2025-09-28Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorFerreira, Rui
dc.contributor.authorMartins, Mariana
dc.contributor.authorSantos, Vanessa
dc.contributor.authorSardinha, Duarte
dc.contributor.authorTavares, Wilson
dc.contributor.authorSabina, Samuel
dc.contributor.authorEspinel, Guacimara
dc.contributor.authorBarreto, Maria Carmo
dc.contributor.authorOliveira, Luísa
dc.contributor.authorCabrera, Raimundo
dc.contributor.authorCastilho, Paula
dc.contributor.editorKitić, Dušanka
dc.contributor.editorŠavikin, Katarina
dc.contributor.editorRandjelović, Milica
dc.date.accessioned2026-01-27T15:04:30Z
dc.date.available2026-01-27T15:04:30Z
dc.date.issued2025-09-28
dc.description.abstractABSTRACT: Essential oils (EOs) from the leaves of Origanum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens, representing three chemotypes—thymol-rich, carvacrol-rich, and a mixed thymol–carvacrol type—were chemically characterized and comparatively assessed for their antifungal, insecticidal, and enzyme-inhibitory activities. This integrated approach provides a comparative assessment of all three chemotypes across multiple biological models, including phytopathogenic fungi, insect bioassays, and key enzyme targets. All EOs displayed antifungal activity for the tested phytopathogenic fungi (Alternaria alternata, Botrytis cinerea, and Fusarium oxysporum) at concentrations above 0.5 mg/mL, with the thymol-rich chemotype showing the highest activity. The minimum inhibition concentration for Oidium farinosum conidial growth was determined and found to be similar for thymol and carvacrol chemotypes and lower for the terpene mixture. Insect control activity was evaluated by an antifeeding assay, where carvacrol and especially thymol chemotypes can be classified as feeding deterrents. EOs and standards revealed a weak toxicity against Ceratitis capitata, with less than 20% mortality at a concentration of 50 mg/mL, and both chemotypes were found to be ineffective in preventing egg deposition. The acetylcholinesterase (AChE) inhibition assay revealed that carvacrol had the greatest inhibitory effect on AChE, followed by EOs, and, finally, thymol. Regarding the α- and β-glucosidase (α- and β-GLU) inhibitory assays, thymol had the strongest inhibitory effect on α-GLU, while plant β-GLU was not inhibited by the standards or OEs.eng
dc.identifier.citationFerreira, R., Martins, M., Santos, V., Sardinha, D., Tavares, W. R., Sabina, S., Espinel, G., Barreto, M. C., Oliveira, L., Cabrera, R., & Castilho, P. (2025). Origanum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens essential oils: Chemotypes and bioactivity as antifungal, antifeeding and enzyme inhibitors. Plants, 14(19), 3001. https://doi.org/10.3390/plants14193001
dc.identifier.doi10.3390/plants14193001
dc.identifier.eissn2223-7747
dc.identifier.urihttp://hdl.handle.net/10400.3/8840
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationEuropean Union - Interreg MAC 2014–2020 Program
dc.relationEuropean Union - MACBIOPEST project (MAC2/1.1a/289)
dc.relationFCT – Fundação para a Ciência e a Tecnologia with Portuguese Government - CQM Base Fund—UIDB/00674/2020 (DOI: 10.54499/UIDB/00674/2020)
dc.relationFCT – Fundação para a Ciência e a Tecnologia with Portuguese Government - Programmatic Fund – UIDP/00674/2020 (DOI: 10.54499/UIDP/00674/2020)
dc.relationARDITI - Agência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação - Região Autónoma da Madeira - Governo Regional (M2030-FSE+-01277200)
dc.relationMACBIOPEST (MAC2/1.1a/289), the program Interreg MAC 2014-2020 - European Regional Development Fund (FEDER)
dc.relationFCT- Fundação para a Ciência e Tecnologia with a PhD grant reference 2020.07711.BD
dc.relation.hasversionhttps://www.mdpi.com/2223-7747/14/19/3001
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectOriganum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens
dc.subjectessential oil
dc.subjectantifungal activity
dc.subjectantifeeding activity
dc.subjectacetylcholinesterase
dc.subjectα-glucosidase
dc.subjectβ-glucosidase
dc.subjectphytopathogen
dc.titleOriganum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens Essential Oils: Chemotypes and Bioactivity as Antifungal, Antifeeding and Enzyme Inhibitorseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage3023
oaire.citation.issue19
oaire.citation.startPage3001
oaire.citation.titlePlants
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameTavares
person.familyNameBarreto
person.familyNameOliveira
person.givenNameWilson
person.givenNameMaria Carmo
person.givenNameLuísa
person.identifier.ciencia-idA216-AC77-3E2F
person.identifier.orcid0000-0001-9817-2756
person.identifier.orcid0000-0001-8377-616X
person.identifier.orcid0000-0001-5162-8875
person.identifier.ridK-3421-2013
person.identifier.scopus-author-id37076751100
person.identifier.scopus-author-id7201790241
relation.isAuthorOfPublication79814483-802c-4a18-8a2a-d748d5e4cd0f
relation.isAuthorOfPublicationa6d28571-a4a1-4882-8bef-6e3ec3b359dd
relation.isAuthorOfPublicationd9a63ca9-d63c-4343-8f6e-9ac27f0bd812
relation.isAuthorOfPublication.latestForDiscovery79814483-802c-4a18-8a2a-d748d5e4cd0f

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