Evaluation of Respiratory, Genotoxic and Cytotoxic Effects from Occupational Exposure to Typography Activities

Linhares, Diana P.; Rocha, Joana Gonçalves; Rodrigues, Armindo; Camarinho, Ricardo; Garcia, Patrícia

Publication

Evaluation of Respiratory, Genotoxic and Cytotoxic Effects from Occupational Exposure to Typography Activities

2023-03-15Journal article

dc.contributor.author	Linhares, Diana P.
dc.contributor.author	Rocha, Joana Gonçalves
dc.contributor.author	Rodrigues, Armindo
dc.contributor.author	Camarinho, Ricardo
dc.contributor.author	Garcia, Patrícia
dc.date.accessioned	2023-04-03T16:53:13Z
dc.date.available	2023-04-03T16:53:13Z
dc.date.issued	2023-03-15
dc.description.abstract	This cross-sectional study was structured to allow the evaluation of the respiratory, genotoxic, and cytotoxic effects of occupational exposure to products resulting from the activity of printers in typographies and, to determine the risk of genotoxicity associated with such exposure. This study comprised 69 subjects, 25 individuals occupationally exposed to the products of typographies (study group), and 44 individuals non-exposed to the environment studied (reference group). The frequency of micronucleated cells and other nuclear anomalies (binucleated, karyolitic, pyknotic, and karyorrhectic cells) in the oral epithelia of each subject were analyzed. The frequency of micronucleated cells was significantly higher in the study group when compared to the reference one (12.96 MN/2000 cells vs. 4 MN/2000 cells, respectively). Occupational exposure to products of typography is a risk factor for the occurrence of micronucleated cells in the study group (RR = 3.2; 95% CI, 2.7–3.9; p < 0.001). The results of the spirometry test did not reveal significant respiratory effects between the reference and study groups.	en
dc.description.sponsorship	FUNDING: This work was financially supported by Azores DRCT Plurianual Funding (M1.1.A/ Func.UI&D/010/2021-2024) and by the Fundo Regional da Ciência (Regional Government of the Azores) (Diana Linhares post-doc fellowship-M3.1.a/F/004/2018).	en
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Linhares, D., Rocha, J., Rodrigues, A., Camarinho, R. & Garcia, P. (2023). Evaluation of respiratory, genotoxic and cytotoxic effects from occupational exposure to typography activities. "Atmosphere", 14(3), 562. DOI:10.3390/atmos14030562.	en
dc.identifier.doi	10.3390/atmos14030562	pt_PT
dc.identifier.issn	2073-4433
dc.identifier.uri	http://hdl.handle.net/10400.3/6674
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	MDPI	pt_PT
dc.relation.publisherversion	https://www.mdpi.com/2073-4433/14/3/562	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Micronuclei	en
dc.subject	Spirometry	en
dc.subject	Printing Office	en
dc.subject	VOC	pt_PT
dc.title	Evaluation of Respiratory, Genotoxic and Cytotoxic Effects from Occupational Exposure to Typography Activities	en
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.conferencePlace	Switzerland	en
oaire.citation.issue	(3)	pt_PT
oaire.citation.title	Atmosphere	en
oaire.citation.volume	14	pt_PT
person.familyName	dos Santos Rodrigues
person.familyName	Camarinho
person.familyName	Garcia
person.givenName	Armindo
person.givenName	Ricardo
person.givenName	Patrícia
person.identifier.ciencia-id	141A-9835-FBE0
person.identifier.ciencia-id	941F-888A-412F
person.identifier.orcid	0000-0002-9851-5429
person.identifier.orcid	0000-0003-1386-7204
person.identifier.orcid	0000-0003-4490-9905
person.identifier.rid	M-7754-2013
person.identifier.scopus-author-id	55775310500
person.identifier.scopus-author-id	7201694062
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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