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Exploring the Therapeutic Potential of Artemisia and Salvia Genera in Cancer, Diabetes, and Cardiovascular Diseases: A Short Review of Clinical Evidence

2025-02-06Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorTavares, Wilson
dc.contributor.authorSeca, Ana
dc.contributor.authorBarreto, Maria Carmo
dc.contributor.editorFukuda, Tatsuya
dc.date.accessioned2026-01-26T10:39:10Z
dc.date.available2026-01-26T10:39:10Z
dc.date.issued2025-02-06
dc.description.abstractABSTRACT: Metabolic syndrome, a cluster of metabolic disorders comprising dyslipidemia, insulin resistance, elevated blood pressure, and abdominal obesity, is a silent epidemic that may lead to outcomes such as cardiovascular disease, diabetes, and cancer. Due to the increase in the prevalence of these pathologies, the search for better treatments and more efficient drugs is imperative. Species of Artemisia and Salvia genera are excellent examples of noteworthy sources of bioactive products with health applications, their therapeutic properties being well known both in popular medicine and in the scientific community. There are reports of plant extracts or compounds from species belonging to either of these genera, which were able to combat cancer, diabetes, and cardiovascular pathologies. For instance, dihydroartemisinin (analog of artemisin extracted from Artemisia annua L.) can reduce tumor markers p53 and Ki-67 expression levels, leading to a reduction in tumor proliferation. Salvia officinalis L. has antihyperglycemic and lipid profile-improving effects since it decreases total cholesterol, glycosylated hemoglobin, fasting glucose, low-density lipoprotein cholesterol, and triglyceride levels while increasing high-density lipoprotein cholesterol levels. Clinical trials using mixtures (dried powdered plants or extracts) of known medicinal plants are recurrent in published works, in contrast with the scarce clinical trial studies with isolated compounds. Salvia miltiorrhiza Bunge. was by far the most targeted plant in the clinical trials analyzed here. Regarding clinical trials concerning Artemisia, there are more studies aiming to see its effect on diabetes, but the studies about cancer are more advanced. This review aims to give a critical summary of the most interesting and promising results from clinical trials. The abundance of studies with limited statistically significant clinical evidence hinders progress in clinical therapy. This situation demands far greater rigor from the scientific community, researchers, regulatory agencies, editors, and reviewers in conducting and publishing clinical studies.eng
dc.identifier.citationTavares, W. R., Seca, A. M. L., & Barreto, M. C. (2025). Exploring the Therapeutic Potential of Artemisia and Salvia Genera in Cancer, Diabetes, and Cardiovascular Diseases: A Short Review of Clinical Evidence. Journal of Clinical Medicine, 14(3), 1028. https://doi.org/10.3390/jcm14031028
dc.identifier.doi10.3390/jcm14031028
dc.identifier.eissn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.3/8806
dc.language.isoeng
dc.peerreviewedn/a
dc.publisherMDPI
dc.relationFCT—Fundação para a Ciência e a Tecnologia through national and European funds, co-financed by DRCT (Azores Regional Government) - M3.1.a/F/029/2022 and co-financed by the European Social Fund
dc.relationRegional Operational Programme Centro 2020, the European Union
dc.relationQREN, FEDER, and COMPETE, funding the cE3c center (FCT-UIDB/00329/2020-2024 and UID/00329/2025)
dc.relationLAQV-REQUIMTE (UIDB/50006/2020 and UIDP/50006/2020)
dc.relation.hasversionhttps://www.mdpi.com/2077-0383/14/3/1028
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectSalvia
dc.subjectArtemisia
dc.subjectclinical trial
dc.subjectmetabolic disorders
dc.subjectanticancer
dc.subjectcardiovascular diseases
dc.subjectdiabetes
dc.subjectdyslipidemia
dc.subjectSalvia miltiorrhiza depside salt
dc.titleExploring the Therapeutic Potential of Artemisia and Salvia Genera in Cancer, Diabetes, and Cardiovascular Diseases: A Short Review of Clinical Evidenceeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage1060
oaire.citation.issue3
oaire.citation.startPage1028
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameTavares
person.familyNameSeca
person.familyNameBarreto
person.givenNameWilson
person.givenNameAna
person.givenNameMaria Carmo
person.identifier.ciencia-id4518-FF32-251F
person.identifier.orcid0000-0001-9817-2756
person.identifier.orcid0000-0002-7709-2375
person.identifier.orcid0000-0001-8377-616X
person.identifier.ridE-5475-2013
person.identifier.scopus-author-id6603279232
person.identifier.scopus-author-id37076751100
relation.isAuthorOfPublication79814483-802c-4a18-8a2a-d748d5e4cd0f
relation.isAuthorOfPublication1c6b511a-fd49-4292-a8a2-b738f558eef1
relation.isAuthorOfPublicationa6d28571-a4a1-4882-8bef-6e3ec3b359dd
relation.isAuthorOfPublication.latestForDiscovery79814483-802c-4a18-8a2a-d748d5e4cd0f

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