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Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism

2023-08-14Journal article Open access
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dc.contributor.authorNavarro-Sempere, A.
dc.contributor.authorMartínez-Peinado, P.
dc.contributor.authorRodrigues, A. S.
dc.contributor.authorGarcia, Patrícia
dc.contributor.authorCamarinho, R.
dc.contributor.authorGrindlay, G.
dc.contributor.authorGras, L.
dc.contributor.authorGarcía, M.
dc.contributor.authorSegovia, Y.
dc.date.accessioned2024-01-15T10:27:40Z
dc.date.available2024-01-15T10:27:40Z
dc.date.issued2023-08-14
dc.description.abstractABSTRACT: It has been reported that volcanoes release several tonnes of mercury per year among other heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high percentage of the world's population lives in the vicinity of an active volcano, the aim of this study is to evaluate the accumulation of these metals in the central nervous system and the presence of cellular mechanisms of heavy metal detoxification such as metallothioneins. To carry out this study, wild mice (Mus musculus) chronically exposed to an active volcanic environment were captured in Furnas village (Azores, Portugal) and compared with those trapped in a reference area (Rabo de Peixe, Azores, Portugal). On the one hand, the heavy metal load has been evaluated by analyzing brain and cerebellum using ICP-MS and a mercury analyzer and on the other hand, the presence of metallothionein 2A has been studied by immunofluorescence assays. Our results show a higher load of metals such as mercury, cadmium and lead in the central nervous system of exposed mice compared to non-exposed individuals and, in addition, a higher immunoreactivity for metallothionein 2A in different areas of the cerebrum and cerebellum indicating a possible neuroprotection process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNavarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A. S., Garcia, P. V., Camarinho, R., Grindlay, G., Gras, L., García, M., & Segovia, Y. (2023). Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism. "Environmental Geochemistry and Health", 45(11), 8257-8269. DOI:10.1007/s10653-023-01722-5 (IF2021 4,898; Q1 Water Resources)pt_PT
dc.identifier.doi10.1007/s10653-023-01722-5pt_PT
dc.identifier.eissn1573-2983
dc.identifier.issn0269-4042
dc.identifier.urihttp://hdl.handle.net/10400.3/6843
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectMus musculuspt_PT
dc.subjectVolcanogenic Pollutionpt_PT
dc.subjectMetalspt_PT
dc.titleMetallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.endPage8269pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage8257pt_PT
oaire.citation.titleEnvironmental Geochemistry and Healthpt_PT
oaire.citation.volume45pt_PT
person.familyNameGarcia
person.givenNamePatrícia
person.identifier.ciencia-id941F-888A-412F
person.identifier.orcid0000-0003-4490-9905
person.identifier.ridM-7754-2013
person.identifier.scopus-author-id7201694062
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94864ead-4016-4db1-b56e-136d294db238
relation.isAuthorOfPublication.latestForDiscovery94864ead-4016-4db1-b56e-136d294db238

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