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Epithelial morphometric alterations and mucosecretory responses in the nasal cavity of mice chronically exposed to hydrothermal emissions

2022-08Journal article Open access
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dc.contributor.authorCamarinho, Ricardo
dc.contributor.authorPardo, A. Madrero
dc.contributor.authorGarcia, Patrícia
dc.contributor.authorRodrigues, Armindo
dc.date.accessioned2021-10-13T12:36:55Z
dc.date.available2022-08-01T00:30:37Z
dc.date.issued2022-08
dc.description.abstractAir pollutants (either of natural or anthropogenic origin) represent a considerable environmental risk to human health by affecting the respiratory system and causing respiratory disorders. In this study, we investigate the effects of chronic exposure to hydrothermal emissions on the nasal cavity of mice since it is the first and the most exposed region of the respiratory system. This study, carried in S. Miguel Island, Azores—Portugal, used Mus musculus as a bioindicator species. Mice were captured in an area with non-eruptive active volcanism (Furnas Village) and another area without volcanism (Rabo de Peixe, reference site). The hydrothermal emissions present at Furnas Village are characterized by the continuous release of several gases (CO₂, H₂S, ²²²Rn) along with metals (e.g. Hg, Cd, Zn, Al) and particulate matter into the environment. We test the hypothesis whether chronic exposure to this specific type of pollution causes epithelial morphometric, mucosecretory and neuronal alterations on the nasal cavity. Thickness measurements were taken in the squamous, respiratory and olfactory epithelia. The relative density of cell types (basal, support and neurons) was also assessed in the olfactory epithelium and the mucosecretory activity was determined in the lateral nasal glands, Bowman’s gland and goblet cells. Mice chronically exposed to hydrothermal emissions presented thinner olfactory epithelia and lesser mucous production, which could result in loss of olfactory capabilities as well as a decrease in the protective function provided by the mucous to the lower respiratory tract. For the first time, it is demonstrated that, in mice, this specific type of non-eruptive active volcanism causes epithelial and mucosecretory alterations, leading to the loss of olfactory capabilities.en
dc.description.sponsorshipRicardo Camarinho is currently supported by a Ph.D. fellowship grant (M3.1.a/F/048/2015) from Fundo Regional da Ciencia (Regional Government of the Azores).en
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCamarinho R., Pardo A.M., Garcia P.V., Rodrigues A.S. (2022). Epithelial morphometric alterations and mucosecretory responses in the nasal cavity of mice chronically exposed to hydrothermal emissions. “Environmental Geochemistry and Health”, 44(8), 2783–2797. DOI: 10.1007/s10653-021-01067-x.pt_PT
dc.identifier.doi10.1007/s10653-021-01067-xpt_PT
dc.identifier.eissn1573-2983
dc.identifier.issn0269-4042
dc.identifier.pmid34448062
dc.identifier.urihttp://hdl.handle.net/10400.3/6092
dc.identifier.wos000691064600002
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationACCORES-01-0145-FEDER-002 GPS Azorespt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs10653-021-01067-xpt_PT
dc.subjectAir Pollutionen
dc.subjectMus musculuspt_PT
dc.subjectNon-eruptive Volcanismen
dc.subjectHydrothermal Emissionsen
dc.subjectNasal Cavityen
dc.subjectHistomorphometryen
dc.titleEpithelial morphometric alterations and mucosecretory responses in the nasal cavity of mice chronically exposed to hydrothermal emissionsen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNetherlandsen
oaire.citation.titleEnvironmental Geochemistry and Healthen
oaire.citation.volume133pt_PT
person.familyNameCamarinho
person.familyNameGarcia
person.familyNamedos Santos Rodrigues
person.givenNameRicardo
person.givenNamePatrícia
person.givenNameArmindo
person.identifier.ciencia-id941F-888A-412F
person.identifier.ciencia-id141A-9835-FBE0
person.identifier.orcid0000-0003-1386-7204
person.identifier.orcid0000-0003-4490-9905
person.identifier.orcid0000-0002-9851-5429
person.identifier.ridM-7754-2013
person.identifier.scopus-author-id55775310500
person.identifier.scopus-author-id7201694062
rcaap.embargofctRequisito do periódico (SHERPA/ROMEO)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd3673693-ee44-4231-8744-c0b494c0d5d0
relation.isAuthorOfPublication94864ead-4016-4db1-b56e-136d294db238
relation.isAuthorOfPublication375991d8-6f81-4403-902c-000634a4cfdd
relation.isAuthorOfPublication.latestForDiscovery375991d8-6f81-4403-902c-000634a4cfdd

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