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Blood elemental levels and antioxidant markers in humans with atherosclerotic disease

2003-10Conference object Open access
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dc.contributor.authorLopes, Paula Alexandra
dc.contributor.authorNapoleão, Patrícia
dc.contributor.authorPinheiro, Teresa
dc.contributor.authorSantos, Maria Cristina
dc.contributor.authorRodrigues, Maria Odete
dc.contributor.authorCeia, Fátima
dc.contributor.authorVicente, Luís
dc.contributor.authorMathias, Maria da Luz
dc.contributor.authorPavão, Maria Leonor
dc.contributor.authorNève, Jean
dc.contributor.authorViegas-Crespo, Ana Maria
dc.date.accessioned2014-02-19T11:35:37Z
dc.date.available2014-02-19T11:35:37Z
dc.date.issued2003-10
dc.descriptionProceeding de 4th International Symposium "Trace Elements in Human: New Perspectives", 9 a 11 Outubro 2003 – Atenas, Grécia, Ed. S Ermidou, S Pollet, Novartis (Hellas) Grécia.en
dc.description.abstractAlthough mortality from coronary heart disease has declined recently, atherosclerosis and related vascular diseases are still the major cause of death in the western countries. Experimental studies have demosntrated that a disturbed balance between free radical formation and antioxidant defenses can play a role in the development and progression of various diseases, namely atherosclerosis. In this study trace element levels were measured in plasma and in blood cells of subjects suffering from atherosclerotic disease. Blood activities of antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPx) and plasma total thiols were also evaluated in these patients. Significantly decreased Se and Fe were found in the blood plasma of the atherosclerotic group. A tendency for disruption in antioxidant enzyme status was observed in these patients, but plasma total thiols were unchanged. These are preliminary results and a large atherosclerotic group is required in order to clarify the observations and to contribute for the knowledge on the molecular basis of atherosclerosis.en
dc.description.sponsorshipFundação para a Ciência e a Tecnologia.por
dc.identifier.citationLOPES, P. A., NAPOLEÃO, P., PINHEIRO, T., SANTOS, M. C., RODRIGUES, M. O., CEIA, F., VICENTE, L., MATHIAS, M. L., PAVÃO, M. L., NÈVE, J., e VIEGAS-CRESPO, A. M. (2003). "Blood elemental levels and antioxidant markers in humans with atherosclerotic disease". In Proceedings of 4th International Symposium on trace elements in Human: New perspectives, Parte I, 9 a 11 Outubro – Atenas, Grécia, Ed. S Ermidou, S Pollet, Novartis (Hellas) Grécia:155-162.en
dc.identifier.urihttp://hdl.handle.net/10400.3/2789
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTrace Elements in Human: New Perspectivesen
dc.relationMarkers of the prooxidant/antioxidant balance and characterization of the allelic profile of apo E in inhabitants of Lisbon and Ponta Delgada
dc.subjectAtherosclerosisen
dc.subjectOxidative Stressen
dc.subjectTrace Elementsen
dc.subjectAntioxidant Enzymesen
dc.subjectTotal Thiolsen
dc.titleBlood elemental levels and antioxidant markers in humans with atherosclerotic diseaseen
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMarkers of the prooxidant/antioxidant balance and characterization of the allelic profile of apo E in inhabitants of Lisbon and Ponta Delgada
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FESP%2F41008%2F2001/PT
oaire.citation.conferencePlaceAthens, Greeceen
oaire.citation.endPage162por
oaire.citation.startPage155por
oaire.citation.titleProceedings of the 4th International Symposium "Trace Elements in Human: New Perspectives"en
oaire.fundingStreamPOCI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isProjectOfPublicationb5aee06b-d4f3-4fc9-a05e-108e590dd046
relation.isProjectOfPublication.latestForDiscoveryb5aee06b-d4f3-4fc9-a05e-108e590dd046

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