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Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells

dc.contributor.authorGarcia, Patrícia
dc.contributor.authorLinhares, Diana P.
dc.contributor.authorAmaral, A. F. S.
dc.contributor.authorRodrigues, Armindo
dc.date.accessioned2013-03-11T17:34:21Z
dc.date.available2013-03-11T17:34:21Z
dc.date.issued2012-09
dc.descriptionCopyright © 2012 Elsevier B.V. All rights reserved.en
dc.description.abstractThermoelectric power-plant workers are constantly exposed to high levels of potentially genotoxic gaseous substances, such as volatile organic compounds (VOCs) from the combustion of fuel oil or the processing of naphtha. The aim of the present study was to estimate the association between such occupational exposure and the frequency of micronucleated cells and cells with other nuclear anomalies. Buccal epithelial cells were collected from a total of 44 power-plant workers (exposed group) and 47 administrative workers (non-exposed group), and examined for the frequency of micronucleated cells (MNC) and of cells with other nuclear anomalies (ONA: pyknosis, karyolysis, and karyorrhexis) by means of the micronucleus assay. The frequencies of MNC and ONA per 1000 cells in the exposed group (1.8‰ and 82.4‰, respectively) were significantly higher than in the non-exposed group (0.2‰ and 58.3‰, respectively). The exposed group had a twelve-fold increase in risk for formation of MNC compared with non-exposed individuals (RR = 12.1; 95% CI, 5.0–29.2; P < 0.001). The confounding factors analyzed (age, smoking status, alcohol consumption, and mouthwash use) did not show any significant association with the frequency of MNC or ONA. The findings of this study show that workers from power plants exposed to VOCs have a significantly elevated risk for DNA damage. Therefore, bio-monitoring of DNA damage is recommended for this group of workers.en
dc.identifier.citationGarcia, P., Linhares, D., Amaral, A.F.S. &. Rodrigues, A. (2012). "Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells". «Mutation Research/Genetic Toxicology and Environmental Mutagenesis», 747(2): 197-201. http://dx.doi.org/10.1016/j.mrgentox.2012.05.008.en
dc.identifier.issn1383-5718
dc.identifier.urihttp://hdl.handle.net/10400.3/1667
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.mrgentox.2012.05.008por
dc.subjectVOCspor
dc.subjectDNA Damageen
dc.subjectBio-Monitoringen
dc.subjectBuccal Exfoliated Cellsen
dc.subjectMicronucleien
dc.subjectOccupational Exposureen
dc.titleExposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cellsen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage201por
oaire.citation.issue(2)por
oaire.citation.startPage197por
oaire.citation.titleMutation Research/Genetic Toxicology and Environmental Mutagenesisen
oaire.citation.volume747por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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