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Chemical study and biological activity evaluation of two Azorean Macroalgae: Ulva rigida and Gelidium microdon

2013-04Journal article Open access
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dc.contributor.authorSilva, Madalena
dc.contributor.authorVieira, Luís M.
dc.contributor.authorAlmeida, Ana Paula
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorSeca, Ana M. L.
dc.contributor.authorBarreto, Maria do Carmo
dc.contributor.authorNeto, Ana I.
dc.contributor.authorPedro, Madalena
dc.contributor.authorPinto, Eugénia
dc.contributor.authorKijjoa, Anake
dc.date.accessioned2013-07-26T09:42:46Z
dc.date.available2013-07-26T09:42:46Z
dc.date.issued2013-04
dc.descriptionCopyright: © 2013 Silva M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite.en
dc.description.abstractThe green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active against some fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.en
dc.identifier.citationSilva M, Vieira L, Almeida AP, Silva A, Seca A, Barreto MC, Neto AI, Pedro M, Pinto E & Kijjoa A (2013) (published online). "Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae: Ulva rigida and Gelidium microdon". «Oceanography», 1(1): 102.en
dc.identifier.issn2332-2632
dc.identifier.urihttp://hdl.handle.net/10400.3/2163
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherOMICS Publishing Groupen
dc.relation.publisherversionhttp://www.esciencecentral.org/journals/OCN/OCN-1-102.php?aid=13974
dc.subjectAzoresen
dc.subjectMacroalgaeen
dc.subjectUlva rigidapor
dc.subjectGelidium microdonpor
dc.subjectIsofucosterolpor
dc.subject7(E)-3β-hydroxy-5α,6α-epoxymegastigmanepor
dc.subject(+)-dehydrovomifoliolpor
dc.subjectLumichromeen
dc.subjectAntitumoren
dc.subjectAntimicrobialen
dc.titleChemical study and biological activity evaluation of two Azorean Macroalgae: Ulva rigida and Gelidium microdonen
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PTDC/MAR/100482/2008
oaire.citation.conferencePlaceN/Apor
oaire.citation.endPage7por
oaire.citation.issueN/Apor
oaire.citation.startPage1por
oaire.citation.titleOceanographyen
oaire.citation.volume1por
oaire.fundingStreamPTDC
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublicationad6d25ee-7292-46db-8d2c-d2050200bc9a
relation.isProjectOfPublication.latestForDiscoveryad6d25ee-7292-46db-8d2c-d2050200bc9a

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