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Cross-sectional study of risk factors for atherosclerosis in the Azorean population

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dc.contributor.authorCymbron, Teresa
dc.contributor.authorRaposo, Mafalda
dc.contributor.authorKazachkova, Nadia
dc.contributor.authorBettencourt, Conceição
dc.contributor.authorSilva, Francisca
dc.contributor.authorSantos, Cristina
dc.contributor.authorDahmani, Yahya
dc.contributor.authorLourenço, Paula C.
dc.contributor.authorFerin, Rita
dc.contributor.authorPavão, Maria Leonor
dc.contributor.authorLima, Manuela
dc.date.accessioned2014-02-11T12:55:37Z
dc.date.available2014-02-11T12:55:37Z
dc.date.issued2011
dc.descriptionCopyright © 2011 Informa UK Ltd.en
dc.description.abstractBackground: Atherosclerosis -a major cause of vascular disease, including ischemic heart disease (IHD), is a pathology that has a two-fold higher mortality rate in the Azorean Islands compared to mainland Portugal. Aim: This cross-sectional study investigated the role of genetic variation in the prevalence of atherosclerosis in this population. Subjects and methods: A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE. Data were analysed with respect to phenotypic characteristics such as blood pressure, lipid profile, life-style risk factors and familial history of myocardial infarction. Results: In the total sample, frequencies for hypercholestrolemic, hypertensive and obese individuals were 63.6%, 39.3% and 23.3%, respectively. The genetic profile was similar to that observed in other European populations, namely in mainland Portugal. No over-representation of risk alleles was evidenced in this sample. Conclusions: One has to consider the possibility of an important non-genetic influence on the high cholesterolemia present in the Azorean population. Since diet is the most important life-style risk factor for dyslipidemia, studies aiming to evaluate the dietary characteristics of this population and its impact on serum lipid levels will be of major importance.en
dc.description.sponsorshipGoverno Regional dos Açores; Instituto de Biotecnologia e Biomedicina dos Açores.por
dc.identifier.citationCYMBRON, T., RAPOSO, M., KAZACHKOVA, N., BETTENCOURT, C., SILVA, F., SANTOS, C., DAHMANI, Y., LOURENÇO, P., FERIN, R., PAVÃO, M.L: & LIMA (2011). "Cross-sectional study of risk factors for atherosclerosis in the Azorean population", Annals of Human Biology, 2011, Early Online: 1-6. http://dx.doi.org/10.3109/03014460.2011.553203.en
dc.identifier.issn0301-4460 (Print)
dc.identifier.issn1464-5033 (Online)
dc.identifier.urihttp://hdl.handle.net/10400.3/2744
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherInforma Healthcareen
dc.relation.publisherversionhttp://informahealthcare.com/doi/abs/10.3109/03014460.2011.553203por
dc.subjectPolymorphismsen
dc.subjectSusceptibility Genesen
dc.subjectAtherosclerosisen
dc.subjectIschemic Heart Diseaseen
dc.subjectAzorespen
dc.titleCross-sectional study of risk factors for atherosclerosis in the Azorean populationpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/BD/34322/2007
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/BPD/38659/2007
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/BPD/63121/2009
oaire.citation.endPage6por
oaire.citation.startPage1por
oaire.citation.titleAnnals of Human Biologyen
oaire.citation.volumeearly onlineen
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isProjectOfPublication6d10b003-999d-4316-9b3a-c05a6a7962dd
relation.isProjectOfPublication94524766-db4a-469c-8b12-8db1856f1071
relation.isProjectOfPublication.latestForDiscovery6d10b003-999d-4316-9b3a-c05a6a7962dd

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