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Trace element levels and redox markers in human atherosclerosis: relationship with Apo E Polymorphism

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dc.contributor.authorLopes, Paula Alexandra
dc.contributor.authorNapoleão, Patrícia
dc.contributor.authorPinheiro, Teresa
dc.contributor.authorSantos, Maria Cristina
dc.contributor.authorRodrigues, Maria Odete
dc.contributor.authorCosta, Luciana
dc.contributor.authorCeia, Fátima
dc.contributor.authorVicente, Luís
dc.contributor.authorPavão, Maria Leonor
dc.contributor.authorNève, Jean
dc.contributor.authorViegas-Crespo, Ana Maria
dc.date.accessioned2014-02-21T16:31:48Z
dc.date.available2014-02-21T16:31:48Z
dc.date.issued2004
dc.descriptionAbstract de Comunicação em Painel apresentada em "VIIth International Conference of the International Society for Trace Elements Research in Humans (ISTERH)-Trace Element Nutrition and Human Disease", 7-12 Nov, 2004, Bangkok, Tailândia.por
dc.description.abstractOxidation of LDL in the vessel wall plays an important role in the development of atherosclerotic lesions mediated by several mechanisms. Measurement of antioxidant/oxidant-related parameters and trace element levels in serum in parallel with the allelic profile of apo E may be useful in assessing the risk of atherogenesis in humans. Blood activities of antioxidant enzymes, SOD and GPx, total thiols, caeruloplasmin, α-tocopherol as well as products of oxidative damage, MDA and protein carbonyls were evaluated in patients with diagnostic atherosclerosis in parallel with matched healthy subjects. The elemental levels were assessed in plasma and blood cell fractions. The allelic frequencies of apo E were similar to those referred in the literature. Significantly decreased K, Fe and Zn levels were found in plasma of the atherosclerotic group. A tendency for a disruption in antioxidant enzyme status was observed in patients, although serum caeruloplasmin and α-tocopherol contents were unchanged. Plasma protein carbonyls levels were decreased in patients. This study could contribute for a better understanding of the relationship between genetic and redox balance markers, which is of utmost importance for the prevention of atherosclerosis.en
dc.identifier.citationLOPES, P. A., NAPOLEÃO, P., PINHEIRO, T.; SANTOS, M. C., RODRIGUES, M. O., COSTA, L., CEIA, F., VICENTE, L., PAVÃO, M. L., NÈVE, J. e VIEGAS-CRESPO, A. M. (2004). "Trace element levels and redox markers in human atherosclerosis: relationship with Apo E Polymorphism", VIIth International Conference of the International Society for Trace Elements Research in Humans (ISTERH) - “Trace Element Nutrition and Human Disease”, Bangkok, Tailândia, 7-12 de Novembro. (Resumo: The Journal of Trace Elements in Experimental Medicine, 2004, 17(4), 204-205. http://dx.doi.org/10.1002/jtra.20012.)en
dc.identifier.urihttp://hdl.handle.net/10400.3/2813
dc.language.isoengpor
dc.publisherWiley-Lisspor
dc.relation.publisherversionhttp://dx.doi.org/10.1002/jtra.20012por
dc.subjectAtherosclerosisen
dc.titleTrace element levels and redox markers in human atherosclerosis: relationship with Apo E Polymorphismen
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage205por
oaire.citation.issue(4)por
oaire.citation.startPage204por
oaire.citation.titleThe Journal of Trace Elements in Experimental Medicineen
oaire.citation.volume17por
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor

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