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Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
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Orientador(es)
Resumo(s)
The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e., chelerythrine, sanguinarine, berberine and coptisine, both with malate+glutamate or with succinate as substrates. When malate+glutamate was used as substrate, chelerythrine and berberine, which contain methoxy groups, were particularly more active, since they had a strong effect even at low concentrations. In submitochondrial particles, berberine and coptisine had a marked inhibitory effect on NADH dehydrogenase activity but practically no effect on succinate dehydrogenase activity, whereas chelerythrine and sanguinarine inhibited more strongly succinate dehydrogenase than NADH dehydrogenase, which is in agreement with the results found for mitochondrial respiration. Protopine and allocryptopine, which did not inhibit mitochondrial respiration, strongly inhibited NADH dehydrogenase in submitochondrial particles, but had no effect on succinate dehydrogenase activity.
Descrição
Copyright © 2003 Elsevier Ireland Ltd. All rights reserved.
Palavras-chave
Protoberberine Alkaloids Benzophenanthridine Alkaloids Structure–activity Relationship Mitochondrial Respiration NADH Dehydrogenase Succinate Dehydrogenase
Contexto Educativo
Citação
BARRETO, M.C., PINTO, R.E., ARRABAÇA, J.D. & PAVÃO M.L. (2003). "Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids". «Toxicology Letters», 146(1), 37-47. [Article In Press].
Editora
Elsevier