Bioactive meroditerpenes from Cystoseira abies-marina, collected from the coast of S. Miguel island

Gouveia, Vera L. M.; Seca, Ana M. L.; Barreto, Maria do Carmo; Silva, Artur M. S.; Kijjoa, Anake

Publication

Bioactive meroditerpenes from Cystoseira abies-marina, collected from the coast of S. Miguel island

2012-11Conference object

dc.contributor.author	Gouveia, Vera L. M.
dc.contributor.author	Seca, Ana M. L.
dc.contributor.author	Barreto, Maria do Carmo
dc.contributor.author	Silva, Artur M. S.
dc.contributor.author	Kijjoa, Anake
dc.date.accessioned	2014-03-28T14:01:28Z
dc.date.available	2014-03-28T14:01:28Z
dc.date.issued	2012-11
dc.description	3rd Portuguese Meeting on Medicinal Chemistry and 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, Aveiro, 28-30 Novembro 2012.	en
dc.description.abstract	Many substances isolated from marine organisms have demonstrated to possess interesting biological and pharmacological activities and have been used as leads in the development of new pharmaceutical agents. Marine macroalgae are abundant and structuring organisms of the coastal area of all the islands in the Azores Archipelago; some have a markedly seasonal pattern and others are perennial and present during the whole year in the Azorean coasts. One of these is Cystoseira abies-marina which grows abundantly in the coast of the Azores archipelago. Interestingly, it was observed in situ that this alga was not attacked by common predators, such as marine gastropods which led to the suggestion that the great resistance to predation of this species was due to the presence of potentially active compounds, such as antifeedant and/or cytotoxic. Preliminary study on the extracts of Cystoseira abies-marina, collected in S. Miguel Island, showed very promising results for antitumour and antioxidant activities [3]. These results have increased our interest in this alga and led to its phytochemical study. Recently, we have reported the isolation and identification of benzoic acid and two new meronorsesquiterpenes [Cystoazores A (1) and Cystoazores B (2)] from the extracts of this marine alga [4]. Further investigation of this species led to isolation of other two new meroditerpene derivatives (3 and 4). We report here the isolation of the compounds 3 and 4, from Cystoseira abies-marina whose structures were established by 1D and 2D NMR spectral analysis as well as by MS. Additionally, the cytotoxic, anti-inflammatory and antioxidant activities of compounds 1-4 were evaluated and the results will be presented.	en
dc.description.sponsorship	Thanks are due to Fundação para a Ciência e Tecnologia of Portugal (projects PTDC/MAR/100482/2008 and PEst-C/QUI/UI0062/2011 and the Portuguese National NMR Network-RNRMN), FEDER and CIIMAR (Plurianual Program) for financial support.	en
dc.identifier.citation	Gouveia, Vera L. M.; Seca, Ana M. L.; Barreto, Maria do Carmo; Silva, Artur M. S.; Kijjoa, Anake (2012). "Bioactive meroditerpenes from Cystoseira abies-marina, collected from the coast of S. Miguel island". 3rd Portuguese Meeting on Medicinal Chemistry and 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, Aveiro, 28-30 Novembro 2012, P127, pag. 179 (Poster Communications).	en
dc.identifier.uri	http://hdl.handle.net/10400.3/2925
dc.language.iso	eng	por
dc.peerreviewed	yes	por
dc.publisher	Universidade de Aveiro/SPQ	por
dc.subject	Cystoseira abies-marina	por
dc.subject	Meroditerpenoids	en
dc.subject	Anticancer	en
dc.subject	Antoixidant	en
dc.title	Bioactive meroditerpenes from Cystoseira abies-marina, collected from the coast of S. Miguel island	en
dc.type	conference object
dspace.entity.type	Publication
oaire.awardURI	info:eu-repo/grantAgreement/FCT/PTDC/MAR/100482/2008
oaire.awardURI	info:eu-repo/grantAgreement/FCT/PEst-C/QUI/UI0062/2011
oaire.citation.conferencePlace	Aveiro, Portugal	por
oaire.citation.endPage	179	por
oaire.citation.startPage	179	por
oaire.citation.title	3º Encontro Nacional Química Terapêutica	por
oaire.fundingStream	PTDC
oaire.fundingStream	PEst-C
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	por
rcaap.type	conferenceObject	por
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