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Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study

dc.contributor.authorLopes, Paula Alexandra
dc.contributor.authorNapoleão, Patrícia
dc.contributor.authorPinheiro, Teresa
dc.contributor.authorCeia, Fátima
dc.contributor.authorSteghens, Jean-Paul
dc.contributor.authorPavão, Maria Leonor
dc.contributor.authorSantos, Maria Cristina
dc.contributor.authorViegas-Crespo, Ana Maria
dc.date.accessioned2014-02-11T11:55:01Z
dc.date.available2014-02-11T11:55:01Z
dc.date.issued2006
dc.descriptionCopyright © 2006 by Humana Press Inc.en
dc.descriptionArtigo original publicado por Humana Press Inc. Actual Editora da Revista Biological Trace Element Research: Springer [A publicação original está disponível em www.springerlink.com].en
dc.description.abstractProspective studies have demonstrated that an imbalance between oxidative damage and antioxidative protection can play a role in the development and progression of atherosclerosis. Also, genotypes with the apolipoprotein E ζ4 allele have been associated with an increase risk for this pathology. Based on this knowledge, the aim of this study was to evaluate indicators of the redox balance, trace elements, and apolipoprotein E allelic profile in subjects from the Lisbon population with clinically stable atherosclerosis, at risk for atherosclerotic events, and in healthy subjects for comparison. The activities of superoxide dismutase in erythrocytes and glutathione peroxidase in whole blood, plasma total thiols, and serum ceruloplasmin were kept unchanged among the three groups. Serum α-tocopherol was increased in atherosclerotic patients. Total malondialdehyde in serum and protein carbonyls in plasma, which are indicators of lipid and protein oxidative damage, respectively, reached their highest values in risk subjects. The concentrations of potassium and calcium, in plasma and in blood cells, were slightly elevated in patients and might reflect an electrolytic imbalance. Regarding the apolipoprotein E polymorphism, atherosclerotic patients had an increased incidence of the high-risk genotypes for atherogenesis (ζ3/ζ4 and ζ4/ζ4). A multivariate model applied to the general population using most of the parameters clearly separated the three groups at study (i.e., the healthy group from the steady-state group of risk disease and from the atherosclerotic one). As shown by us, the usefulness of biochemical and complementary genetic markers is warranted for a better knowledge on atherosclerosis molecular basis.en
dc.description.sponsorshipFundação para a Ciência e a Tecnologia; Centro de Biologia Ambiental; Instituto de Investigação Científica Bento da Rocha Cabral; Instituto Nacional de Saúde Dr. Ricardo Jorge.por
dc.identifier.citationLOPES, P. A., NAPOLEÃO, P., PINHEIRO, T., CEIA, F., STEGHENS, J. P., PAVÃO, M. L., SANTOS, M. C. e VIEGAS-CRESPO, A. M. (2006). "Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study". Biological Trace Element Research, 112(1): 57-75. http://dx.doi.org/10.1385/BTER:112:1:57.en
dc.identifier.issn1559-0720 (Online)
dc.identifier.issn0163-4984 (Print)
dc.identifier.urihttp://hdl.handle.net/10400.3/2742
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHumana Press Inc.por
dc.relationMarkers of the prooxidant/antioxidant balance and characterization of the allelic profile of apo E in inhabitants of Lisbon and Ponta Delgada
dc.relation.publisherversionhttp://www.springer.com/life+sciences/biochemistry+%26+biophysics/journal/12011por
dc.subjectAtherosclerosisen
dc.subjectAntioxidant Defensesen
dc.subjectOxidative Damageen
dc.subjectTrace Elementsen
dc.subjectApolipoprotein Een
dc.titleSystemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Studyen
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarkers of the prooxidant/antioxidant balance and characterization of the allelic profile of apo E in inhabitants of Lisbon and Ponta Delgada
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FESP%2F41008%2F2001/PT
oaire.citation.endPage75por
oaire.citation.issue(1)por
oaire.citation.startPage57por
oaire.citation.titleBiological Trace Element Researchen
oaire.citation.volume112por
oaire.fundingStreamPOCI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublicationb5aee06b-d4f3-4fc9-a05e-108e590dd046
relation.isProjectOfPublication.latestForDiscoveryb5aee06b-d4f3-4fc9-a05e-108e590dd046

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