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A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves

2011-03Journal article Restricted access
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dc.contributor.authorMoujir, Laila M.
dc.contributor.authorSeca, Ana M. L.
dc.contributor.authorAraujo, Liliana
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorBarreto, Maria do Carmo
dc.date.accessioned2014-03-31T12:04:29Z
dc.date.available2014-03-31T12:04:29Z
dc.date.issued2011-03
dc.date.updated2014-03-27T21:22:05Z
dc.descriptionCopyright © 2010 Elsevier B.V. All rights reserved.en
dc.description.abstractA new natural spiro compound 3,4-dehydrotheaspirone 1 and the known arctiol [1β,6α-dihydroxy-4(14)-eudesmene] 2 were isolated from Juniperus brevifolia. Arctiol is reported for the first time in the Juniperus genus. Their structures were established by 1D, and 2D NMR and MS spectra. Antimicrobial and cytotoxic activities of 1 and several secondary metabolites 3,4,5,6,7,8,9,10,11,12 previously isolated by our group from J. brevifolia were evaluated and some SAR has been established. The 18-hydroxydehydroabietane displayed great antiproliferative activity against cancer cell lines tested, namely HeLa, A-549 and MCF-7. Compound also presented a significant bactericidal effect against Bacillus cereus at different concentrations tested.en
dc.identifier.citationMoujir, Laila M.; Seca, Ana M.L.; Araujo, Liliana; Silva, Artur M.S.; Barreto, M. Carmo (2011). "A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves", Fitoterapia, 82(2), 225-229. DOI: 10.1016/j.fitote.2010.10.001.en
dc.identifier.issn0367-326X (Print)
dc.identifier.issn1873-6971 (Online)
dc.identifier.urihttp://hdl.handle.net/10400.3/2939
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.fitote.2010.10.001por
dc.subject3,4-Dehydrotheaspironepor
dc.subjectCupressaceaeen
dc.subjectJuniperus brevifoliapor
dc.subjectDiterpenesen
dc.subjectCytotoxicityen
dc.subjectAntimicrobial Activityen
dc.titleA new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leavesen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage229por
oaire.citation.issue(2)por
oaire.citation.startPage225por
oaire.citation.titleFitoterapiaen
oaire.citation.volume82por
rcaap.rightsclosedAccesspor
rcaap.typearticlepor

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