Departamento de Ciências da Física, Química e Engenharia
URI permanente desta comunidade:
Navegar
Percorrer Departamento de Ciências da Física, Química e Engenharia por assunto "Acetylcholinesterase Inhibitors"
A mostrar 1 - 1 de 1
Resultados por página
Opções de ordenação
- Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agentsPublication . Seca, Ana M. L.; Leal, Stephanie B.; Pinto, Diana C. G. A.; Barreto, Maria do Carmo; Silva, Artur M. S.Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 μM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 μM) when compared to galantamine (IC50 = 211.8 ± 9.5 μM).