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Grupo de Biodiversidade dos Açores

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Percorrer Grupo de Biodiversidade dos Açores por Domínios Científicos e Tecnológicos (FOS) "Ciências Médicas::Biotecnologia Médica"

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  • Ionic Liquids and Deep Eutectic Solvents for Polyphenol Extraction: Opportunities and Limitations
    Publication . Rosa, Gonçalo; Barreto, Maria do Carmo; Seca, Ana; Pinto, Diana; Vlase, Ana-Maria
    Polyphenols are structurally diverse plant secondary metabolites with broad biological activities and growing applications across the food, health, and materials sectors. Conventional extraction based on organic solvents (e.g., methanol, ethanol) is often energy-intensive, inefficient, and environmentally burdensome. Ionic liquids (ILs) and deep eutectic solvents (DESs) have therefore emerged as greener alternatives for polyphenol extraction. This review evaluates recent advances in solvent design, extraction performance, and process sustainability. Imidazolium-based ILs frequently achieve high yields and selectivity, particularly when coupled with ultrasound or microwave-assisted extraction, but high cost, synthetic complexity, viscosity-related constraints, and potential toxicity hinder scaleup. By contrast, DESs—especially those derived from choline chloride or lactic acid—are easier to prepare, less costly, and more compatible with industrial implementation, with efficiency enhanced by tailoring hydrogen bond networks, water content, and process intensification. Critical downstream challenges persist for both solvent classes, notably in extract purification and solvent recovery due to low volatility; approaches such as resin adsorption, antisolvent precipitation, and direct formulation have been explored. Overall, ILs and DESs represent compelling alternatives to conventional solvents, and future progress will depend on integrated extraction–recovery strategies, systematic solvent selection, and validation under scalable, sustainable processing conditions.
    2026-04-15Artigo de investigação Acesso aberto Ver mais