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Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina
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Orientador(es)
Resumo(s)
Two new meronorsesquiterpenes (cystoazorones A and B) and two new meroditerpenes (cystoazorols A and B), along with benzoic acid were isolated from the brown macroalga Cystoseira abies-marina. The structures of the new compounds were established by 1D and 2D NMR as well as HRMS spectral analysis. The in vitro cytotoxicity and antioxidant activity of the isolated compounds were also evaluated. Cystoazorones A and B, and cystoazorol A exhibited in vitro growth inhibitory activity against HeLa cells. The HeLa cell line in log phase was found to be more sensitive to cystoazorol A than when it was in lag phase. Cystoazorol A also showed a selectivity index higher than taxol, which was used as a positive control. Cystoazorols A and B were found to be the strongest antioxidants among the compounds tested.
Descrição
Copyright © 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Palavras-chave
Cystoseira abies-marina Phaeophyceae Meronorsesquiterpenes Meroditerpenes Cytotoxicity
Contexto Educativo
Citação
Gouveia, Vera L.M.; Seca, Ana M.L.; Barreto, M. Carmo; Neto, Ana I.; Kijjoa, Anake; Silva, Artur M.S. (2013). "Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina", «Phytochemistry Letters», 6(4), 593-597. http://dx.doi.org/10.1016/j.phytol.2013.07.012.