Please use this identifier to cite or link to this item:
http://hdl.handle.net/10400.3/2939| Title: | A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves |
| Author: | Moujir, Laila M. Seca, Ana M. L. Araujo, Liliana Silva, Artur M. S. Barreto, Maria do Carmo |
| Keywords: | 3,4-Dehydrotheaspirone Cupressaceae Juniperus brevifolia Diterpenes Cytotoxicity Antimicrobial Activity |
| Issue Date: | Mar-2011 |
| Publisher: | Elsevier |
| Citation: | Moujir, Laila M.; Seca, Ana M.L.; Araujo, Liliana; Silva, Artur M.S.; Barreto, M. Carmo (2011). "A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves", Fitoterapia, 82(2), 225-229. DOI: 10.1016/j.fitote.2010.10.001. |
| Abstract: | A new natural spiro compound 3,4-dehydrotheaspirone 1 and the known arctiol [1β,6α-dihydroxy-4(14)-eudesmene] 2 were isolated from Juniperus brevifolia. Arctiol is reported for the first time in the Juniperus genus. Their structures were established by 1D, and 2D NMR and MS spectra. Antimicrobial and cytotoxic activities of 1 and several secondary metabolites 3,4,5,6,7,8,9,10,11,12 previously isolated by our group from J. brevifolia were evaluated and some SAR has been established. The 18-hydroxydehydroabietane displayed great antiproliferative activity against cancer cell lines tested, namely HeLa, A-549 and MCF-7. Compound also presented a significant bactericidal effect against Bacillus cereus at different concentrations tested. |
| Description: | Copyright © 2010 Elsevier B.V. All rights reserved. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10400.3/2939 |
| ISSN: | 0367-326X (Print) 1873-6971 (Online) |
| Publisher Version: | http://dx.doi.org/10.1016/j.fitote.2010.10.001 |
| Appears in Collections: | DCFQE - Artigos em Revistas Internacionais / Articles in International Journals |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Fitoterapia 2011 J brevifolia actividades.pdf | 558,14 kB | Adobe PDF | View/Open Request a copy |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
