Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/2750
Título: Plasma aminothiol status in the population of the Island of São Jorge (The Azores Archipelago, Portugal)
Autor: Ferin, Rita
Correia, Cristina
Raposo, Mafalda
Gonçalves, Bruno
Gonçalves, C.
Baptista, José
Pavão, Maria Leonor
Palavras-chave: Atherosclerosis
Plasma Aminothiol Profile (PAP)
Data: Jun-2010
Editora: Elsevier
Citação: FERIN, R., CORREIA, C., RAPOSO, M., GONÇALVES, B., GONÇALVES, C., BAPTISTA, J. E PAVÃO, M. L. (2010). "Plasma aminothiol status in the population of the Island of São Jorge (The Azores Archipelago, Portugal)", Atherosclerosis Supplements, 2010, 11(2): 163-164. [Abstracts of the 78th EAS Congress]. http://dx.doi.org/10.1016/S1567-5688(10)70770-4.
Resumo: Hcy, Cys, Cys-Gly and GSH are low molecular weight thiols that play important roles in the metabolism and homeostasis of the organism. An altered plasma aminothiols status can cause oxidative stress, thus contributing to atherogenesis. The aim of this study was to evaluate the plasma levels of total Hcy, Cys, Cys-Gly and GSH, as well as GGT activity in apparently healthy subjects from the Island of S˜ao Jorge, taking into consideration gender and lipid profile. The study group was formed by 73 subjects with no chronic diseases, aged 20 to 60 years, born living in the island of S˜ao Jorge. The evaluation of the four aminothiols was carried out by HPLC with an isocratic reversephase column using a fluorescence detector. Mean values of GSH (1.8±0.6mM) and Cys (240±35mM) content were under reference values, but Cys-Gly was above. Plasma total Hcy, Cys and Cys-Gly levels, as well as GGT activity were significantly higher in men than in women (respectively, 30%, 7%, 17% and 65%). About 63% of subjects were hyperlipidemic, mainly hypercholesterolemic. Cys concentration was increased by 9% in hyperlipidemics vs. normolipidemics. In subjects with altered thiol status men, but not women, revealed a moderate hyperhomocysteinemia. Also Cys-Gly concentrations were significantly higher in men than in women. In spite of being apparently healthy, all subjects (namely men) have depleted antioxidant defenses, indicating high oxidative stress. Alterations in plasma GSH, Cys-Gly and Cys concentrations, taken together, and independently of dyslipidemia, could be considered as early markers of atherosclerosis.
Descrição: 78th Congress of the European- Atherosclerosis -Society (AES): Abstract MS269.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10400.3/2750
ISSN: 1567-5688
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S1567568810707704
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