Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/2744
Título: Cross-sectional study of risk factors for atherosclerosis in the Azorean population
Autor: Cymbron, Teresa
Raposo, Mafalda
Kazachkova, Nadia
Bettencourt, Conceição
Silva, Francisca
Santos, Cristina
Dahmani, Yahya
Lourenço, Paula C.
Ferin, Rita
Pavão, Maria Leonor
Lima, Manuela
Palavras-chave: Polymorphisms
Susceptibility Genes
Ischemic Heart Disease
Data: 2011
Editora: Informa Healthcare
Citação: CYMBRON, T., RAPOSO, M., KAZACHKOVA, N., BETTENCOURT, C., SILVA, F., SANTOS, C., DAHMANI, Y., LOURENÇO, P., FERIN, R., PAVÃO, M.L: & LIMA (2011). "Cross-sectional study of risk factors for atherosclerosis in the Azorean population", Annals of Human Biology, 2011, Early Online: 1-6. http://dx.doi.org/10.3109/03014460.2011.553203.
Resumo: Background: Atherosclerosis -a major cause of vascular disease, including ischemic heart disease (IHD), is a pathology that has a two-fold higher mortality rate in the Azorean Islands compared to mainland Portugal. Aim: This cross-sectional study investigated the role of genetic variation in the prevalence of atherosclerosis in this population. Subjects and methods: A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE. Data were analysed with respect to phenotypic characteristics such as blood pressure, lipid profile, life-style risk factors and familial history of myocardial infarction. Results: In the total sample, frequencies for hypercholestrolemic, hypertensive and obese individuals were 63.6%, 39.3% and 23.3%, respectively. The genetic profile was similar to that observed in other European populations, namely in mainland Portugal. No over-representation of risk alleles was evidenced in this sample. Conclusions: One has to consider the possibility of an important non-genetic influence on the high cholesterolemia present in the Azorean population. Since diet is the most important life-style risk factor for dyslipidemia, studies aiming to evaluate the dietary characteristics of this population and its impact on serum lipid levels will be of major importance.
Descrição: Copyright © 2011 Informa UK Ltd.
Peer review: yes
URI: http://hdl.handle.net/10400.3/2744
ISSN: 0301-4460 (Print)
1464-5033 (Online)
Versão do Editor: http://informahealthcare.com/doi/abs/10.3109/03014460.2011.553203
Aparece nas colecções:DCFQE - Artigos em Revistas Internacionais / Articles in International Journals

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