Utilize este identificador para referenciar este registo:
|Título:||Cross-sectional study of risk factors for atherosclerosis in the Azorean population|
Lourenço, Paula C.
Pavão, Maria Leonor
Ischemic Heart Disease
|Citação:||CYMBRON, T., RAPOSO, M., KAZACHKOVA, N., BETTENCOURT, C., SILVA, F., SANTOS, C., DAHMANI, Y., LOURENÇO, P., FERIN, R., PAVÃO, M.L: & LIMA (2011). "Cross-sectional study of risk factors for atherosclerosis in the Azorean population", Annals of Human Biology, 2011, Early Online: 1-6. http://dx.doi.org/10.3109/03014460.2011.553203.|
|Resumo:||Background: Atherosclerosis -a major cause of vascular disease, including ischemic heart disease (IHD), is a pathology that has a two-fold higher mortality rate in the Azorean Islands compared to mainland Portugal. Aim: This cross-sectional study investigated the role of genetic variation in the prevalence of atherosclerosis in this population. Subjects and methods: A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE. Data were analysed with respect to phenotypic characteristics such as blood pressure, lipid profile, life-style risk factors and familial history of myocardial infarction. Results: In the total sample, frequencies for hypercholestrolemic, hypertensive and obese individuals were 63.6%, 39.3% and 23.3%, respectively. The genetic profile was similar to that observed in other European populations, namely in mainland Portugal. No over-representation of risk alleles was evidenced in this sample. Conclusions: One has to consider the possibility of an important non-genetic influence on the high cholesterolemia present in the Azorean population. Since diet is the most important life-style risk factor for dyslipidemia, studies aiming to evaluate the dietary characteristics of this population and its impact on serum lipid levels will be of major importance.|
|Descrição:||Copyright © 2011 Informa UK Ltd.|
|Versão do Editor:||http://informahealthcare.com/doi/abs/10.3109/03014460.2011.553203|
|Aparece nas colecções:||DCFQE - Artigos em Revistas Internacionais / Articles in International Journals|
Ficheiros deste registo:
|Cymbron_et_al_2011_Annals_human_biology.pdf||118,15 kB||Adobe PDF||Ver/Abrir|
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.