Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/3182
Título: Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents
Autor: Seca, Ana M. L.
Leal, Stephanie B.
Pinto, Diana C. G. A.
Barreto, Maria do Carmo
Silva, Artur M. S.
Palavras-chave: Xanthene-1,9(2H)-diones
Scavenging Activity
Reduction Power
Acetylcholinesterase Inhibitors
Xanthones
3-cinnamoyl-5-hydroxy-2-styrylchromones
Data: Jun-2014
Editora: MDPI
Citação: Seca, Ana; Leal, Stephanie; Pinto, Diana; Barreto, Maria; Silva, Artur (2014). "Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents", Molecules, 19(6), 8317-8333. Doi: 10.3390/molecules19068317.
Resumo: Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 μM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 μM) when compared to galantamine (IC50 = 211.8 ± 9.5 μM).
Peer review: yes
URI: http://hdl.handle.net/10400.3/3182
DOI: 10.3390/molecules19068317
ISSN: 1420-3049
Versão do Editor: http://www.mdpi.com/1420-3049/19/6/8317
Aparece nas colecções:DCTD - Artigos em Revistas Internacionais / Articles in International Journals

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