Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/2815
Título: Blood antioxidant markers and elemental levels in Azorean patients with coronary artery disease: a preliminary study
Autor: Ferin, Rita
Napoleão, Patrícia
Gomes, Carla
Castro, Ana Rita
Lopes, Paula Alexandra
Martins, Dinis
Santos, Maria Cristina
Viegas-Crespo, Ana Maria
Pinheiro, Teresa
Pavão, Maria Leonor
Palavras-chave: Atherosclerosis
Cardiovascular Risk Factors
Data: Jun-2008
Editora: Springer
Citação: FERIN, R., NAPOLEÃO, P., GOMES, C., CASTRO, A.R., LOPES, P.A., MARTINS, D., SANTOS, M. C., VIEGAS-CRESPO, A. M., PINHEIRO, T. e PAVÃO, M. L. (2008). "Blood antioxidant markers and elemental levels in Azorean patients with coronary artery disease: a preliminary study", VIIIth Conference of the International Society for Trace Element Research in Humans (ISTERH), IXth Conference of the Nordic Trace Element Society (NTES) and VIth Conference of the Helenic Trace Element Society (HTES)Cell Biology and Toxicology, 2007, Hersonissos, Crete-Greece, 21-26 October (Resumo: Cell Biology and Toxicology, 2008, 24(S1), S33-S34. http://dx.doi.org/10.1007/s10565-007-9052-8)
Resumo: Atherosclerosis (ATH) and related vascular diseases are the first cause of morbidity and mortality in Portugal, including the Azores’ Archipelago. The oxidation of low density lipoproteins (LDL) is considered to be an important event in the development of the disease. Accordingly, by preventing LDL oxidation, antioxidants can possibly reduce the risk or the progression of ATH. Essential trace elements as Cu, Se, Zn, and Fe are involved in endogenous antioxidant systems, mainly as cofactors of antioxidant enzymes. Other elements, like K and Ca, might play a role in atherogenesis while implicated in physiological and metabolic processes which are known to be disturbed in ATH. The aimof the present study was to evaluate some blood antioxidant markers and blood elemental levels in 20 Azorean subjects (ten men and ten women, aged 40 to 65 years) with coronary artery disease previously submitted to percutaneous revascularization (PCI). The whole blood gluthatione peroxidase (Se-GPx) and erythrocyte superoxide dismutase activities were measured, as well as serum vitamin E levels (by HPLC). The concentrations of K, Ca, Fe, Cu, Zn, and Se in plasma and blood cells were determined by PIXE. Results were analyzed by taking into account several cardiovascular risk factors, namely, gender, hypertension, dyslipidemia, and total plasma homocysteine (tHcy) concentration. Se-GPx activity and vitamin E levels were significantly lower (24 and 15%, respectively) in the PCI group than in controls. In blood cells, significantly differences in Ca (19±5 vs 24±6 μg/mL) and Zn (14±1 vs 12±2 μg/mL) levels were observed in PCI women (but not in men) compared to the respective counterparts. Also in PCI women, both serum triglyceride and plasma tHcy concentrations were above reference values and higher than in men. Results suggest a decreased antioxidant status in PCI patients. In particular, women appear to be less protected than men, as reflected in some cardiovascular risk factors.
Descrição: Abstract de comunicação em Painel (3.P01) apresentada em VIIIth Conference of the International Society for Trace Element Research in Humans (ISTERH), IXth Conference of the Nordic Trace Element Society (NTES) and VIth Conference of the Helenic Trace Element Society (HTES),2007,21-26 Out, Hersonissos (Creta), Grécia
URI: http://hdl.handle.net/10400.3/2815
ISSN: 0742-2091 (Print)
1573-6822 (Online)
Versão do Editor: http://dx.doi.org/10.1007/s10565-007-9052-8.
Aparece nas colecções:DCFQE - Comunicações a Conferências / ConferenceItem

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Blood antioxidant markers & elemental levels in Azorean patient.pdf1,87 MBAdobe PDFVer/Abrir
Cell Biol Toxicol (2008) 24 (Suppl 1)_S33–S34.pdf98,12 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.