Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/2741
Título: Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities, serum trace elements (Se, Cu, Zn) and cardiovascular risk factors in subjects from the city of Ponta Delgada (Island of San Miguel, The Azores' Archipelago, Portugal)
Autor: Pavão, Maria Leonor
Figueiredo, Teresa
Santos, Víctor
Lopes, Paula Alexandra
Ferin, Rita
Santos, Maria Cristina
Nève, Jean
Palavras-chave: Antioxidant Biomarkers
Cardiovascular Risk Factors
Azores
Data: 2006
Editora: Informa Healthcare
Citação: PAVÃO, M. L., FIGUEIREDO, T., SANTOS, V., LOPES, P. A., FERIN, R., SANTOS, M. C., NÈVE, J. e VIEGAS CRESPO, A. M. (2006). "Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities, serum trace elements (Se, Cu, Zn) and cardiovascular risk factors in subjects from the city of Ponta Delgada (Island of San Miguel, The Azores' Archipelago, Portugal)". Biomarkers, 11(5), 460-471. http://dx.doi.org/10.1080/13547500600625828.
Resumo: Activities of whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) and serum levels of selenium (Se), copper (Cu) and zinc (Zn) were measured in 118 apparently healthy subjects aged 20–60 years from the city of Ponta Delgada, Island of San Miguel, The Azores Archipelago, Portugal. Data were analysed by age/gender, lipid profile and blood pressure as cardiovascular risk factors searching for their relevance when assessing reference values for antioxidant biomarkers. GSH-Px was in the same range, but SOD was significantly lower than in other Portuguese populations. Neither activity differed with gender. GSH-Px activity increased with age, namely in normolipidemic men versus the hyperlipidemic group in which a decrease was observed. This suggests a progressive impairment of GSH-Px with age caused by an enhanced production of oxidant species in hyperlipidemia. GSH-Px was 30% lower in male hypertensives versus normotensives. SOD activity did not relate to age or blood pressure but was 17% higher in the hyperlipidemic men versus the normolipidemic group, suggesting a better antioxidant protection by SOD than by GSH-Px in hyperlipidemia and hypertension. Se was higher in men versus women, particularly in the older subjects, and partly related to hyperlipidemia. Zn levels showed a similar dependency on gender, not related to age or lipid profile. Cu levels were much higher in women than in men in all age or lipid profile classes and decreased in hyperlipidemia. They were lowered with age in both genders, particularly in normolipidemic women. The present research therefore suggests that hyperlipidemia and hypertension do affect antioxidant status and should be considered when assessing antioxidant biomarkers in blood.
Descrição: Copyright © 2006 Informa UK Ltd.
Peer review: yes
URI: http://hdl.handle.net/10400.3/2741
ISSN: 1354-750X (Print)
1366-5804 (Electronic)
Versão do Editor: http://informahealthcare.com/doi/abs/10.1080/13547500600625828
Aparece nas colecções:DCFQE - Artigos em Revistas Internacionais / Articles in International Journals

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