Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/2342
Título: Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina
Autor: Gouveia, Vera L. M.
Seca, Ana M. L.
Barreto, Maria do Carmo
Neto, Ana I.
Kijjoa, Anake
Silva, Artur M. S.
Palavras-chave: Cystoseira abies-marina
Phaeophyceae
Meronorsesquiterpenes
Meroditerpenes
Cytotoxicity
Data: Nov-2013
Editora: Elsevier
Citação: Gouveia, Vera L.M.; Seca, Ana M.L.; Barreto, M. Carmo; Neto, Ana I.; Kijjoa, Anake; Silva, Artur M.S. (2013). "Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina", «Phytochemistry Letters», 6(4), 593-597. http://dx.doi.org/10.1016/j.phytol.2013.07.012.
Resumo: Two new meronorsesquiterpenes (cystoazorones A and B) and two new meroditerpenes (cystoazorols A and B), along with benzoic acid were isolated from the brown macroalga Cystoseira abies-marina. The structures of the new compounds were established by 1D and 2D NMR as well as HRMS spectral analysis. The in vitro cytotoxicity and antioxidant activity of the isolated compounds were also evaluated. Cystoazorones A and B, and cystoazorol A exhibited in vitro growth inhibitory activity against HeLa cells. The HeLa cell line in log phase was found to be more sensitive to cystoazorol A than when it was in lag phase. Cystoazorol A also showed a selectivity index higher than taxol, which was used as a positive control. Cystoazorols A and B were found to be the strongest antioxidants among the compounds tested.
Descrição: Copyright © 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10400.3/2342
ISSN: 1874-3900
Versão do Editor: http://dx.doi.org/10.1016/j.phytol.2013.07.012
Aparece nas colecções:DCFQE - Artigos em Revistas Internacionais / Articles in International Journals
DBIO - Artigos em Revistas Internacionais / Articles in International Journals

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