Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/2163
Título: Chemical study and biological activity evaluation of two Azorean Macroalgae: Ulva rigida and Gelidium microdon
Autor: Silva, Madalena
Vieira, Luís M.
Almeida, Ana Paula
Silva, Artur M. S.
Seca, Ana M. L.
Barreto, Maria do Carmo
Neto, Ana I.
Pedro, Madalena
Pinto, Eugénia
Kijjoa, Anake
Palavras-chave: Azores
Macroalgae
Ulva rigida
Gelidium microdon
Isofucosterol
7(E)-3β-hydroxy-5α,6α-epoxymegastigmane
(+)-dehydrovomifoliol
Lumichrome
Antitumor
Antimicrobial
Data: Abr-2013
Editora: OMICS Publishing Group
Citação: Silva M, Vieira L, Almeida AP, Silva A, Seca A, Barreto MC, Neto AI, Pedro M, Pinto E & Kijjoa A (2013) (published online). "Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae: Ulva rigida and Gelidium microdon". «Oceanography», 1(1): 102.
Resumo: The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active against some fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.
Descrição: Copyright: © 2013 Silva M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite.
Peer review: yes
URI: http://hdl.handle.net/10400.3/2163
ISSN: 2332-2632
Versão do Editor: http://www.esciencecentral.org/journals/OCN/OCN-1-102.php?aid=13974
Aparece nas colecções:DBIO - Artigos em Revistas Internacionais / Articles in International Journals

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