Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.3/1366
Título: Trace metals and over-expression of metallothioneins in bladder tumoral lesions: a case-control study
Autor: Amaral, André
Cymbron, Teresa
Gärtner, Fátima
Lima, Manuela
Rodrigues, Armindo
Palavras-chave: Cancer
Metallothioneins
Metals
Bladder
Bovine
Data: 18-Jul-2009
Editora: BioMed Central
Citação: "BMC Veterinary Research". ISSN 1746-6148. Volume 5, Issue 24 (2009), 6 pp..
Resumo: Background: Previous studies have provided some evidence of a possible association between cancer and metallothioneins. Whether this relates to an exposure to carcinogenic metals remains unclear. Methods: In order to examine the association between the expression of metallothioneins and bladder tumors, and to compare the levels of arsenic, cadmium, chromium, lead and nickel in animals with bladder tumors and animals without bladder tumors, 37 cases of bovine bladder tumors and 17 controls were collected. The detection and quantification of metallothioneins in bladder tissue of both cases and controls was performed by immunohistochemistry. And the quantification of metals in tissue and hair was assessed by inductively coupled plasma – mass spectrometry. Results: Increased expression of metallothioneins was associated with bladder tumors when compared with non-tumoral bladder tissue (OR = 9.3, 95% CI: 1.0 – 480). The concentrations of cadmium, chromium, lead and nickel in hair of cases were significantly higher than those of controls. However, as for the concentration of metals in bladder tissue, the differences were not significant. Conclusion: Though the sample size was small, the present study shows an association between bladder tumors and metallothioneins. Moreover, it shows that concentrations of metals such as cadmium, chromium, lead and nickel in hair may be used as a biomarker of exposure.
Descrição: © 2009 Amaral et al; licensee BioMed Central Ltd.
Peer review: yes
URI: http://hdl.handle.net/10400.3/1366
ISSN: 1746-6148
Versão do Editor: http://dx.doi.org/10.1186/1746-6148-5-24
Aparece nas colecções:DBIO - Artigos em Revistas Internacionais / Articles in International Journals

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